Angiotensin II regulates the metabolism but not the secretion of vasoactive intestinal peptide in the rabbit.

Davis RE, Macdonald GJ, Duggan KA

Clinical science (London, England : 1979)1 Nov 1992Cited by 4 (Europe PMC)

PMID1335391DOI10.1042/cs0830557PepBankPUB-01335391

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Pharmacokinetics
In rabbits on a high sodium diet, the metabolic clearance rate of the body's own VIP was significantly higher than on a low sodium diet during vehicle infusion (P < 0.01).
In plain wordsIn rabbits, the body's own VIP was cleared faster on a high sodium diet than on a low sodium diet.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP metabolic clearance rate, high versus low sodium diet, vehicle infusion
Study
rabbitn: not reported in source
Comparator
Low sodium diet
Outcome group
Pharmacokinetics · Endocrine and hormones
Source sentences
Summary
The metabolic clearance rate of vasoactive intestinal peptide was significantly higher in rabbits on the high sodium diet during both vehicle control (P < 0.01) and angiotensin II (P < 0.05) infusion.
1 context sentence(design, population, supporting numbers)
Summary · context
We determined the metabolic clearance rate and theoretical secretion rate of vasoactive intestinal peptide in rabbits on low sodium (high circulating angiotensin II) and high sodium (low circulating angiotensin II) diets with and without simultaneous angiotensin II infusion.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0133539101
02AnimalEndogenous levelAnimal study (in vivo)Pharmacokinetics
In rabbits on a high sodium diet, the metabolic clearance rate of the body's own VIP was significantly higher than on a low sodium diet during angiotensin II infusion (P < 0.05).
In plain wordsIn rabbits given angiotensin II, the body's own VIP was cleared faster on a high sodium diet than on a low sodium diet.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP metabolic clearance rate, high versus low sodium diet, angiotensin II infusion
Study
rabbitn: not reported in source
Comparator
Low sodium diet
Outcome group
Pharmacokinetics · Endocrine and hormones
Source sentences
Summary
The metabolic clearance rate of vasoactive intestinal peptide was significantly higher in rabbits on the high sodium diet during both vehicle control (P < 0.01) and angiotensin II (P < 0.05) infusion.
1 context sentence(design, population, supporting numbers)
Summary · context
We determined the metabolic clearance rate and theoretical secretion rate of vasoactive intestinal peptide in rabbits on low sodium (high circulating angiotensin II) and high sodium (low circulating angiotensin II) diets with and without simultaneous angiotensin II infusion.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0133539102
03AnimalEndogenous levelAnimal study (in vivo)Pharmacokinetics
In rabbits on low and high sodium diets, angiotensin II infusion decreased the metabolism of the body's own VIP (P < 0.01 in both).
In plain wordsIn rabbits, angiotensin II slowed the breakdown of the body's own VIP on both low and high sodium diets.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP metabolism with angiotensin II infusion
Study
rabbitn: not reported in source
Comparator
Vehicle infusion
Outcome group
Pharmacokinetics · Endocrine and hormones
Source sentences
Summary
Angiotensin II infusion decreased the metabolism of vasoactive intestinal peptide in rabbits on both low (P < 0.01) and high (P < 0.01) sodium diets.
1 context sentence(design, population, supporting numbers)
Summary · context
We determined the metabolic clearance rate and theoretical secretion rate of vasoactive intestinal peptide in rabbits on low sodium (high circulating angiotensin II) and high sodium (low circulating angiotensin II) diets with and without simultaneous angiotensin II infusion.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0133539103
04AnimalEndogenous levelAnimal study (in vivo)Pharmacokinetics
In rabbits, the theoretical secretion rate of the body's own VIP differed significantly between the two dietary groups under basal conditions (P < 0.025).
In plain wordsIn rabbits, the secretion rate of the body's own VIP differed between the low and high sodium diet groups at rest.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Direction not reportedBasal VIP secretion rate, high versus low sodium diet
Study
rabbitn: not reported in source
Comparator
Other dietary group
Outcome group
Pharmacokinetics · Endocrine and hormones
Source sentences
Summary
Although there was a significant difference in secretion rates between the two dietary groups (P < 0.025) under basal conditions
1 context sentence(design, population, supporting numbers)
Summary · context
We determined the metabolic clearance rate and theoretical secretion rate of vasoactive intestinal peptide in rabbits on low sodium (high circulating angiotensin II) and high sodium (low circulating angiotensin II) diets with and without simultaneous angiotensin II infusion.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0133539104
05AnimalEndogenous levelAnimal study (in vivo)Pharmacokinetics
In rabbits on low and high sodium diets, angiotensin II infusion did not significantly alter the secretion rate of the body's own VIP.
In plain wordsIn rabbits, angiotensin II did not change how much of the body's own VIP was secreted, on either diet.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP secretion rate with angiotensin II infusion
Study
rabbitn: not reported in source
Comparator
Vehicle infusion
Outcome group
Pharmacokinetics · Endocrine and hormones
Source sentences
Summary
infusion of angiotensin II did not alter the secretion rate significantly in either group.
1 context sentence(design, population, supporting numbers)
Summary · context
We determined the metabolic clearance rate and theoretical secretion rate of vasoactive intestinal peptide in rabbits on low sodium (high circulating angiotensin II) and high sodium (low circulating angiotensin II) diets with and without simultaneous angiotensin II infusion.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0133539105

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Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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