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Study · Animal study (in vivo) · cat, mouse and rat · 1992

4 results

[The effect of the delta sleep-inducing peptide on seizure activity].

SHandra AA, Godlevskiĭ LS, Mazarati AM, Oleshko AA, Mikhaleva II

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova1 May 1992

PMID1334876 (opens in a new tab)PepBankPUB-01334876
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cats, DSIP suppressed seizure activity in cortical strychnine-induced seizure foci.

    In plain wordsIn cats, DSIP reduced seizure activity in brain areas where seizures were caused by strychnine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStrychnine-induced cortical seizure foci
    Study

    catn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The delta-sleep-inducing peptide (DSIP) suppressed seizure activity in the cat cortical strychnine-induced seizure foci.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP delayed the development of corazol kindling.

    In plain wordsIn rats, DSIP slowed the development of seizure kindling caused by corazol.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDevelopment of corazol kindling
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The DSIP delayed development of corazol kindling in rats, prevented seizure induced with bicucullin and other agents in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP prevented seizures induced by bicucullin and other agents.

    In plain wordsIn mice, DSIP prevented seizures caused by bicucullin and other agents.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizures induced by bicucullin and other agents
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prevented seizure induced with bicucullin and other agents in mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    The anticonvulsant effect of DSIP was shown to act through the reticular black substance.

    In plain wordsIn animals, the seizure-reducing effect of DSIP was shown to act through a brain region called the reticular black substance.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSite of anticonvulsant action (reticular black substance)
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The DSIP effect was shown to be realised through the action upon reticular black substance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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