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Study · Non-randomized trial · n = 11 · 1992

3 results

A further study on the stimulatory effect of peptide histidine methionine on growth hormone secretion in acromegaly: a dose-related study and a comparison with vasoactive intestinal peptide.

Watanobe H, Takebe K

Neuropeptides1 Oct 1992Cited by 6 (Europe PMC)

PMID1333573 (opens in a new tab)DOI10.1016/0143-4179(92)90088-e (opens in a new tab)PepBankPUB-01333573
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with active acromegaly, an i.v. bolus of VIP 50 micrograms caused a paradoxical GH response in 4 patients (36%).

    In plain wordsIn people with active acromegaly, a 50 microgram VIP injection raised growth hormone abnormally in 36% of patients.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseParadoxical GH response to VIP 50 micrograms
    Study

    n = 11

    Comparator
    Basal GH level
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    50 micrograms · intravenous · single i.v. bolusAs given in this study (human).

    Measurements

    Paradoxical GH responders
    36%
    VIP 50 micrograms

    Source sentences

    Summary
    A paradoxical GH response (> 50% and > 6 micrograms/l above the basal) to 50 or 100 micrograms of VIP was observed in 4 (36%) or 5 (45%) patients, respectively.
    1 context sentence
    Summary · context
    VIP (50 or 100 micrograms) or PHM (50, 100, or 200 micrograms) was given as an i.v. bolus to 11 patients with active acromegaly, and plasma GH levels were measured before and at intervals up to 120 min after the injection.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with active acromegaly, an i.v. bolus of VIP 100 micrograms caused a paradoxical GH response in 5 patients (45%).

    In plain wordsIn people with active acromegaly, a 100 microgram VIP injection raised growth hormone abnormally in 45% of patients.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseParadoxical GH response to VIP 100 micrograms
    Study

    n = 11

    Comparator
    Basal GH level
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenous · single i.v. bolusAs given in this study (human).

    Measurements

    Paradoxical GH responders
    45%
    VIP 100 micrograms

    Source sentences

    Summary
    A paradoxical GH response (> 50% and > 6 micrograms/l above the basal) to 50 or 100 micrograms of VIP was observed in 4 (36%) or 5 (45%) patients, respectively.
    1 context sentence
    Summary · context
    VIP (50 or 100 micrograms) or PHM (50, 100, or 200 micrograms) was given as an i.v. bolus to 11 patients with active acromegaly, and plasma GH levels were measured before and at intervals up to 120 min after the injection.
  3. 03HumanNon-randomized trialOther

    In patients with active acromegaly, 3 of the 5 responders to PHM 200 micrograms also responded to both VIP doses, and one responder to VIP 100 micrograms did not respond to PHM 200 micrograms.

    In plain wordsIn people with acromegaly, most who responded to a high dose of PHM also responded to VIP, but not all.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableOverlap of VIP and PHM GH responders
    Study

    n = 11

    Comparator
    PHM 200 micrograms
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    50 or 100 micrograms · intravenous · single i.v. bolusAs given in this study (human).

    Source sentences

    Summary
    3 of these 5 responders to 200 micrograms of PHM were also responders to both doses of VIP. To add to, one of the responders to 100 micrograms of VIP did not show a positive GH response to even 200 micrograms of PHM.
    1 context sentence
    Summary · context
    VIP (50 or 100 micrograms) or PHM (50, 100, or 200 micrograms) was given as an i.v. bolus to 11 patients with active acromegaly, and plasma GH levels were measured before and at intervals up to 120 min after the injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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