Stimulatory effect of thymic factor(s) on steroidogenesis in cultured rat granulosa cells.

Uzumcu M, Akira S, Lin YC

Life sciences1 Jan 1992Cited by 4 (Europe PMC)

PMID1326691DOI10.1016/0024-3205(92)90359-wPepBankPUB-01326691

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In cultured rat granulosa cells, thymosin alpha‑1 did not mimic the stimulation of steroidogenesis by thymic cell conditioned medium.
In plain wordsIn rat cells in a dish, thymosin alpha‑1 did not copy the hormone-boosting effect of thymic cell medium.
Peptide
Thymosin alpha-1
Outcome
No significant changeSteroidogenesis in granulosa cells
Study
ratn: not reported in source
Cultured granulosa cells from DES-treated immature rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory action of TCM was not mimicked by HCM, thymosin-alpha 1 or thymulin.
1 context sentence(design, population, supporting numbers)
Summary · context
Granulosa cells were obtained from immature diethylstilbestrol (DES)-treated rats.
Report a problemFND-0132669101
02LabIn vitro (cells)Activity measurement
In cultured rat granulosa cells, thymulin did not mimic the stimulation of progesterone secretion produced by TCM.
In plain wordsIn cells from rat ovaries, thymulin did not reproduce the increase in progesterone secretion seen with TCM.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeProgesterone secretion stimulation
Study
ratn: not reported in source
Cultured granulosa cells from immature DES-treated rats
Comparator
Thymic cell culture conditioned medium (TCM)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory action of TCM was not mimicked by HCM, thymosin-alpha 1 or thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
TCM stimulated basal progesterone and estradiol secretion from the granulosa cells in a dose and time dependent manner.
Summary · context
Granulosa cells were obtained from immature diethylstilbestrol (DES)-treated rats.
Report a problemFND-0132669102
03LabIn vitro (cells)Activity measurement
In cultured rat granulosa cells, thymulin did not mimic the stimulation of estradiol secretion produced by TCM.
In plain wordsIn cells from rat ovaries, thymulin did not reproduce the increase in estradiol secretion seen with TCM.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeEstradiol secretion stimulation
Study
ratn: not reported in source
Cultured granulosa cells from immature DES-treated rats
Comparator
Thymic cell culture conditioned medium (TCM)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory action of TCM was not mimicked by HCM, thymosin-alpha 1 or thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
TCM stimulated basal progesterone and estradiol secretion from the granulosa cells in a dose and time dependent manner.
Summary · context
Granulosa cells were obtained from immature diethylstilbestrol (DES)-treated rats.
Report a problemFND-0132669103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 6 to 14Current
28 Oct 2026, 02:02 UTC
The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.
Study results updated
Versions 4 to 5
21 Oct 2026, 13:55 UTC
The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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