Sex differences in the regulation of oxytocin receptors by ovarian steroids in the ventromedial hypothalamus of the rat.

Coirini H, Johnson AE, Schumacher M, McEwen BS

Neuroendocrinology1 Mar 1992Cited by 32 (Europe PMC)

PMID1323800DOI10.1159/000126125PepBankPUB-01323800

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats of both sexes, estradiol benzoate increased oxytocin receptor density in the medial and caudal ventromedial nucleus of the hypothalamus.
In plain wordsIn male and female rats, estradiol benzoate increased oxytocin receptor density in part of the hypothalamus.
Peptide
Oxytocin
Outcome
IncreaseOxytocin receptor density in VMN after estradiol benzoate
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In both sexes, EB increased the density of OTR and the area covered by the receptors at the level of the medial and caudal VMN.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we compared the effects of EB and P on OTR binding between males and females.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0132380001
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats of both sexes, estradiol benzoate increased the area covered by oxytocin receptors in the medial and caudal ventromedial nucleus.
In plain wordsIn male and female rats, estradiol benzoate enlarged the area covered by oxytocin receptors in part of the hypothalamus.
Peptide
Oxytocin
Outcome
IncreaseOxytocin receptor area in VMN after estradiol benzoate
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In both sexes, EB increased the density of OTR and the area covered by the receptors at the level of the medial and caudal VMN.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we compared the effects of EB and P on OTR binding between males and females.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0132380002
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In estrogen-primed female rats, progesterone further increased oxytocin receptor levels in the medial ventromedial nucleus.
In plain wordsIn female rats primed with estrogen, progesterone further increased oxytocin receptor levels in part of the hypothalamus.
Peptide
Oxytocin
Outcome
IncreaseOxytocin receptor level in medial VMN after progesterone in estrogen-primed females
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In estrogen-primed females, P further increased OTR levels in the medial VMN
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we compared the effects of EB and P on OTR binding between males and females.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0132380003
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In estrogen-primed female rats, progesterone further increased the area covered by oxytocin receptors at the caudal level of the ventromedial nucleus.
In plain wordsIn female rats primed with estrogen, progesterone further enlarged the area covered by oxytocin receptors in part of the hypothalamus.
Peptide
Oxytocin
Outcome
IncreaseOxytocin receptor area in caudal VMN after progesterone in estrogen-primed females
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In estrogen-primed females, P further increased OTR levels in the medial VMN and the area covered by OTR at the level of the caudal VMN.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we compared the effects of EB and P on OTR binding between males and females.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0132380004
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In estrogen-primed male rats, progesterone did not modulate oxytocin receptor binding.
In plain wordsIn male rats primed with estrogen, progesterone did not change oxytocin receptor binding.
Peptide
Oxytocin
Outcome
No significant changeOxytocin receptor binding after progesterone in estrogen-primed males
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
By contrast, P did not modulate OTR binding in estrogen-primed males.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we compared the effects of EB and P on OTR binding between males and females.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0132380005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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