A comparison of the in vivo biochemical responses to exogenous parathyroid hormone-(1-34) [PTH-(1-34)] and PTH-related peptide-(1-34) in man.

Fraher LJ, Hodsman AB, Jonas K, Saunders D, Rose CI, Henderson JE, Hendy GN, Goltzman D

The Journal of clinical endocrinology and metabolism1 Aug 1992Cited by 32 (Europe PMC)

PMID1322424DOI10.1210/jcem.75.2.1322424PepBankPUB-01322424

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanNon-randomized trialActivity measurement
In healthy subjects, hPTH(1-34) infusion significantly increased serum total calcium from baseline.
In plain wordsIn healthy people, hPTH infusion increased total blood calcium from baseline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum total calcium
Study
n = 15
Comparator
Baseline
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Source sentences
Summary
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242401
02HumanNon-randomized trialActivity measurement
In healthy subjects, hPTH(1-34) infusion significantly increased serum ionized calcium from baseline.
In plain wordsIn healthy people, hPTH infusion increased ionized blood calcium from baseline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum ionized calcium
Study
n = 15
Comparator
Baseline
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Source sentences
Summary
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242402
03HumanNon-randomized trialActivity measurement
In healthy subjects, hPTH(1-34) infusion significantly increased urinary phosphate from baseline.
In plain wordsIn healthy people, hPTH infusion increased urinary phosphate from baseline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUrinary phosphate
Study
n = 15
Comparator
Baseline
Outcome group
Kidney function · Kidney and urinary
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Source sentences
Summary
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242403
04HumanNon-randomized trialActivity measurement
In healthy subjects, hPTH(1-34) infusion significantly increased urinary cAMP from baseline.
In plain wordsIn healthy people, hPTH infusion increased urinary cAMP from baseline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUrinary cAMP
Study
n = 15
Comparator
Baseline
Outcome group
Kidney function · Kidney and urinary
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Source sentences
Summary
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242404
05HumanNon-randomized trialActivity measurement
In healthy subjects, hPTH(1-34) infusion significantly increased serum 1,25-dihydroxyvitamin D3 from baseline.
In plain wordsIn healthy people, hPTH infusion increased active vitamin D in blood from baseline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum active vitamin D
Study
n = 15
Comparator
Baseline
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Source sentences
Summary
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242405
06HumanNon-randomized trialActivity measurement
In healthy subjects, total calcium increases with hPTH(1-34) were statistically equivalent to those with high-dose hPTHrP(1-34).
In plain wordsIn healthy people, hPTH and high-dose hPTHrP produced statistically equivalent increases in total blood calcium.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTotal calcium response versus high-dose PTHrP
Study
n = 15
Comparator
hPTHrP-(1-34) 80 pmol/kg.h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Serum calcium before high-dose hPTHrP infusion
2.36 mmol/L
high-dose hPTHrP-(1-34), baseline
Serum calcium after high-dose hPTHrP infusion
2.63 mmol/L
high-dose hPTHrP-(1-34)
Source sentences
Summary
For each variable these changes were statistically equivalent to the increases observed during PTH infusion.
4 context sentences(design, population, supporting numbers)
Summary · context
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
Summary · context
However, a 10-fold higher dose of PTHrP significantly increased serum calcium from 2.36 +/- 0.07 to 2.63 +/- 0.16 mmol/L (P less than 0.003),
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242406
07HumanNon-randomized trialActivity measurement
In healthy subjects, ionized calcium increases with hPTH(1-34) were statistically equivalent to those with high-dose hPTHrP(1-34).
In plain wordsIn healthy people, hPTH and high-dose hPTHrP produced statistically equivalent increases in ionized blood calcium.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeIonized calcium response versus high-dose PTHrP
Study
n = 15
Comparator
hPTHrP-(1-34) 80 pmol/kg.h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Ionized calcium before high-dose hPTHrP infusion
1.22 mmol/L
high-dose hPTHrP-(1-34), baseline
Ionized calcium after high-dose hPTHrP infusion
1.39 mmol/L
high-dose hPTHrP-(1-34)
Source sentences
Summary
For each variable these changes were statistically equivalent to the increases observed during PTH infusion.
4 context sentences(design, population, supporting numbers)
Summary · context
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
Summary · context
ionized calcium from 1.22 +/- 0.03 to 1.39 +/- 0.09 mmol/L (P less than 0.003),
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242407
08HumanNon-randomized trialActivity measurement
In healthy subjects, urinary phosphate increases with hPTH(1-34) were statistically equivalent to those with high-dose hPTHrP(1-34).
In plain wordsIn healthy people, hPTH and high-dose hPTHrP produced statistically equivalent increases in urinary phosphate.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeUrinary phosphate response versus high-dose PTHrP
Study
n = 15
Comparator
hPTHrP-(1-34) 80 pmol/kg.h
Outcome group
Kidney function · Kidney and urinary
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Urinary phosphate before high-dose hPTHrP infusion
0.21 mmol/L glomerular filtrate
high-dose hPTHrP-(1-34), baseline
Urinary phosphate after high-dose hPTHrP infusion
0.31 mmol/L glomerular filtrate
high-dose hPTHrP-(1-34)
Source sentences
Summary
For each variable these changes were statistically equivalent to the increases observed during PTH infusion.
Summary
urinary phosphate from 0.21 +/- 0.19 to 0.31 +/- 0.16 mmol/L glomerular filtrate (P less than 0.05)
3 context sentences(design, population, supporting numbers)
Summary · context
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242408
09HumanNon-randomized trialActivity measurement
In healthy subjects, urinary cAMP increases with hPTH(1-34) were statistically equivalent to those with high-dose hPTHrP(1-34).
In plain wordsIn healthy people, hPTH and high-dose hPTHrP produced statistically equivalent increases in urinary cAMP.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeUrinary cAMP response versus high-dose PTHrP
Study
n = 15
Comparator
hPTHrP-(1-34) 80 pmol/kg.h
Outcome group
Kidney function · Kidney and urinary
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Urinary cAMP before high-dose hPTHrP infusion
37 nmol/L glomerular filtrate
high-dose hPTHrP-(1-34), baseline
Urinary cAMP after high-dose hPTHrP infusion
53 nmol/L glomerular filtrate
high-dose hPTHrP-(1-34)
Source sentences
Summary
For each variable these changes were statistically equivalent to the increases observed during PTH infusion.
Summary
urinary cAMP from 37 +/- 18 to 53 +/- 28 nmol/L glomerular filtrate (P less than 0.01)
3 context sentences(design, population, supporting numbers)
Summary · context
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242409
10HumanNon-randomized trialActivity measurement
In healthy subjects, active vitamin D increases with hPTH(1-34) were statistically equivalent to those with high-dose hPTHrP(1-34).
In plain wordsIn healthy people, hPTH and high-dose hPTHrP produced statistically equivalent increases in active vitamin D.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeActive vitamin D response versus high-dose PTHrP
Study
n = 15
Comparator
hPTHrP-(1-34) 80 pmol/kg.h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Serum 1,25-(OH)2D3 before high-dose hPTHrP infusion
29.8 pmol/L
high-dose hPTHrP-(1-34), baseline
Serum 1,25-(OH)2D3 after high-dose hPTHrP infusion
46 pmol/L
high-dose hPTHrP-(1-34)
Source sentences
Summary
For each variable these changes were statistically equivalent to the increases observed during PTH infusion.
Summary
serum 1,25-(OH)2D3 from 29.8 +/- 12.1 to 46.0 +/- 20.3 pmol/L (P less than 0.01)
3 context sentences(design, population, supporting numbers)
Summary · context
PTH infusion resulted in significant increases from basal values in serum total ionized calcium, urinary phosphate and cAMP, and serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2d3].
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242410
11HumanNon-randomized trialPharmacokinetics
In healthy subjects, circulating hPTH(1-34) and high-dose hPTHrP(1-34) concentrations during infusion had a ratio of 1:3.
In plain wordsIn healthy people, circulating hPTH and high-dose hPTHrP concentrations during infusion had a ratio of 1:3.
Peptide
Teriparatide (PTH 1-34)
Outcome
Not applicableCirculating immunoreactive peptide concentration ratio
Study
n = 15
Comparator
High-dose hPTHrP-(1-34)
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
8 pmol/kg.h · intravenous infusion · 12 hAs given in this study (human).
Measurements
Molar ratio of circulating hPTH-(1-34) to hPTHrP-(1-34)
3 PTHrP per 1 PTH (ratio 1:3)
high-dose hPTHrP-(1-34) vs hPTH-(1-34)
Source sentences
Summary
The molar concentrations of circulating immunoreactive PTH-(1-34) and PTHrP-(1-34) (at the higher dose) achieved during infusion were at a ratio of 1:3.
2 context sentences(design, population, supporting numbers)
Summary · context
Therefore, we compared the actions of the synthetic human (h) analogs hPTHrP-(1-34) and hPTH-(1-34) when given by iv infusion to 15 healthy subjects, aged 25 +/- 3 yr.
Summary · context
Three 12-h test infusions were given to each subject in the order: hPTH-(1-34) at a dose of 8 pmol/kg.h, an equimolar dose (8 pmol/kg.h) of PTHrP-(1-34) (low dose), and a 10-fold higher dose (80 pmol/kg.h) of hPTHrP-(1-34) (high dose).
Report a problemFND-0132242411

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1Results postedNCT00377312

7 Day Continuous Parathyroid Hormone IV Infusion

University of Pittsburghn = 11Sept 2006 to Dec 2007

Osteoporosis · Bone Diseases, Endocrine · Hyperparathyroidism

Trial page ClinicalTrials.govUpdated 22 Mar 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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