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Study · Not a test of the peptide alone · 1992

4 results

Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles.

Insel TR, Shapiro LE

Proceedings of the National Academy of Sciences of the United States of America1 Jul 1992Cited by 545 (Europe PMC)

PMID1321430 (opens in a new tab)PMCIDPMC402122 (opens in a new tab)DOI10.1073/pnas.89.13.5981 (opens in a new tab)PepBankPUB-01321430
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the monogamous prairie vole, oxytocin receptor density was highest in the prelimbic cortex, bed nucleus of the stria terminalis, nucleus accumbens, midline thalamic nuclei and lateral amygdala.

    In plain wordsIn prairie voles, oxytocin receptors were densest in several brain areas linked to social behavior.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor density in monogamous prairie vole brain
    Study

    prairie volen: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In the prairie vole, oxytocin receptor density was highest in the prelimbic cortex, bed nucleus of the stria terminalis, nucleus accumbens, midline nuclei of the thalamus, and the lateral aspects of the amygdala.
    1 context sentence
    Summary · context
    By in vitro receptor autoradiography with an iodinated oxytocin analogue, specific binding to brain oxytocin receptors was observed in both the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the polygamous montane vole, little oxytocin receptor binding was seen in those areas; receptors were localized to the lateral septum, ventromedial hypothalamus and cortical amygdala nucleus.

    In plain wordsIn montane voles, oxytocin receptors sat in different brain areas than in prairie voles.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor distribution in polygamous montane vole brain
    Study

    montane volen: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    These brain areas showed little binding in the montane vole, in which oxytocin receptors were localized to the lateral septum, ventromedial nucleus of the hypothalamus, and cortical nucleus of the amygdala.
    1 context sentence
    Summary · context
    By in vitro receptor autoradiography with an iodinated oxytocin analogue, specific binding to brain oxytocin receptors was observed in both the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the monogamous pine vole and the polygamous meadow vole, brain oxytocin receptor distribution showed similar differences.

    In plain wordsIn pine and meadow voles, oxytocin receptors also sat in different brain areas, matching the social behavior of each species.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor distribution in pine and meadow voles
    Study

    pine vole, meadow volen: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Similar differences in brain oxytocin receptor distribution were observed in two additional species, the monogamous pine vole (Microtus pinetorum) and the polygamous meadow vole (Microtus pennsylvanicus).
    1 context sentence
    Summary · context
    By in vitro receptor autoradiography with an iodinated oxytocin analogue, specific binding to brain oxytocin receptors was observed in both the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the montane vole, brain oxytocin receptor distribution changed within 24 hr of parturition, at the same time as the onset of maternal behavior.

    In plain wordsIn montane voles, the pattern of oxytocin receptors in the brain changed within 24 hours of giving birth.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedOxytocin receptor distribution change after parturition
    Study

    montane volen: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, in the montane vole, which shows little affiliative behavior except during the postpartum period, brain oxytocin receptor distribution changed within 24 hr of parturition, concurrent with the onset of maternal behavior.
    1 context sentence
    Summary · context
    By in vitro receptor autoradiography with an iodinated oxytocin analogue, specific binding to brain oxytocin receptors was observed in both the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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