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Study · Animal study (in vivo) · rat · 1992

3 results

Oxytocin--a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies.

Insel TR

Psychoneuroendocrinology1 Jan 1992Cited by 290 (Europe PMC)

PMID1319071 (opens in a new tab)DOI10.1016/0306-4530(92)90073-g (opens in a new tab)PepBankPUB-01319071
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups, central oxytocin selectively decreased the separation response.

    In plain wordsIn rat pups, oxytocin given in the brain reduced the separation response, mimicking social contact.

    Peptide
    Oxytocin
    Outcome
    DecreaseSeparation response in rat pups
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · centralAs given in this study (rat).

    Source sentences

    Summary
    Our new studies in rat pups demonstrate that central OT selectively decreases the separation response, an effect which mimics social contact.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, oxytocin receptor binding in the bed nucleus of the stria terminalis rose by 84% at parturition.

    In plain wordsIn rats, oxytocin receptor binding in one brain region rose by 84% at birth.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin receptor binding in BNST at parturition
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Measurements

    Receptor binding increase
    84%
    BNST at parturition

    Source sentences

    Summary
    At parturition, binding to OT receptors increases 84% in the BNST

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, oxytocin receptor binding in the ventromedial nucleus of the hypothalamus rose by 35% at estrus.

    In plain wordsIn rats, oxytocin receptor binding in one hypothalamic region rose by 35% at estrus.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin receptor binding in VMN at estrus
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Measurements

    Receptor binding increase
    35%
    VMN at estrus

    Source sentences

    Summary
    at estrus, binding increases 35% in the VMN

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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