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Study · Animal study (in vivo) · rat · 1992

8 results

Effects of thymosin alpha-1 on pituitary hormone release.

Milenkovic L, McCann SM

Neuroendocrinology1 Jan 1992Cited by 22 (Europe PMC)

PMID1319003 (opens in a new tab)DOI10.1159/000126091 (opens in a new tab)PepBankPUB-01319003
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious male rats, third-ventricular injection of thymosin alpha‑1 decreased plasma TSH concentration compared with diluent-injected controls.

    In plain wordsIn rats, thymosin alpha‑1 injected into the brain lowered blood TSH compared with controls given diluent.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePlasma TSH after third-ventricular injection
    Study

    ratn: not reported in source

    Conscious male rats, third-ventricle injection
    Comparator
    Diluent
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Following third-ventricular injection of T alpha 1, there was a significant decrease in plasma TSH and ACTH concentrations in comparison with values of control groups injected with diluent.
    1 context sentence
    Summary · context
    To evaluate its effect in vivo we injected the peptide into the third ventricle of conscious male rats and measured the concentration of the pituitary hormones in plasma at different times after the injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious male rats, third-ventricular injection of thymosin alpha‑1 decreased plasma ACTH concentration compared with diluent-injected controls.

    In plain wordsIn rats, thymosin alpha‑1 injected into the brain lowered blood ACTH compared with controls given diluent.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePlasma ACTH after third-ventricular injection
    Study

    ratn: not reported in source

    Conscious male rats, third-ventricle injection
    Comparator
    Diluent
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Following third-ventricular injection of T alpha 1, there was a significant decrease in plasma TSH and ACTH concentrations in comparison with values of control groups injected with diluent.
    1 context sentence
    Summary · context
    To evaluate its effect in vivo we injected the peptide into the third ventricle of conscious male rats and measured the concentration of the pituitary hormones in plasma at different times after the injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious male rats, thymosin alpha‑1 significantly decreased plasma prolactin, at the same dose that lowered TSH.

    In plain wordsIn rats, thymosin alpha‑1 injected into the brain lowered blood prolactin.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePlasma prolactin after third-ventricular injection
    Study

    ratn: not reported in source

    Conscious male rats, third-ventricle injection
    Comparator
    Diluent
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Also, a significant decrease in plasma Prl was observed, with the same dose as for TSH.
    1 context sentence
    Summary · context
    To evaluate its effect in vivo we injected the peptide into the third ventricle of conscious male rats and measured the concentration of the pituitary hormones in plasma at different times after the injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In conscious male rats, thymosin alpha‑1 did not significantly change plasma growth hormone.

    In plain wordsIn rats, thymosin alpha‑1 injected into the brain did not change blood growth hormone.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changePlasma growth hormone after third-ventricular injection
    Study

    ratn: not reported in source

    Conscious male rats, third-ventricle injection
    Comparator
    Diluent
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    On the other hand, there were no significant changes in plasma GH.
    1 context sentence
    Summary · context
    To evaluate its effect in vivo we injected the peptide into the third ventricle of conscious male rats and measured the concentration of the pituitary hormones in plasma at different times after the injection.
  5. 05LabEx vivo tissueEfficacy outcome

    In rat hemipituitaries incubated in vitro, thymosin alpha‑1 evoked a dose-dependent release of TSH.

    In plain wordsIn lab tests on rat pituitary tissue, thymosin alpha‑1 triggered release of TSH in a dose-dependent way.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTSH release from hemipituitaries in vitro
    Study

    ratn: not reported in source

    Rat hemipituitaries incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this system T alpha 1 evoked a dose-dependent release of TSH and ACTH
    1 context sentence
    Summary · context
    To examine if there is any direct effect of T alpha 1 at the pituitary level, we incubated hemipituitaries from male rats in vitro with different concentrations of the peptide.
  6. 06LabEx vivo tissueEfficacy outcome

    In rat hemipituitaries incubated in vitro, thymosin alpha‑1 evoked a dose-dependent release of ACTH.

    In plain wordsIn lab tests on rat pituitary tissue, thymosin alpha‑1 triggered release of ACTH in a dose-dependent way.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseACTH release from hemipituitaries in vitro
    Study

    ratn: not reported in source

    Rat hemipituitaries incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this system T alpha 1 evoked a dose-dependent release of TSH and ACTH
    1 context sentence
    Summary · context
    To examine if there is any direct effect of T alpha 1 at the pituitary level, we incubated hemipituitaries from male rats in vitro with different concentrations of the peptide.
  7. 07LabEx vivo tissueEfficacy outcome

    In rat hemipituitaries incubated in vitro, thymosin alpha‑1 had no effect on prolactin release.

    In plain wordsIn lab tests on rat pituitary tissue, thymosin alpha‑1 did not change prolactin release.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeProlactin release from hemipituitaries in vitro
    Study

    ratn: not reported in source

    Rat hemipituitaries incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while there was no effect on the release of Prl and GH.
    1 context sentence
    Summary · context
    To examine if there is any direct effect of T alpha 1 at the pituitary level, we incubated hemipituitaries from male rats in vitro with different concentrations of the peptide.
  8. 08LabEx vivo tissueEfficacy outcome

    In rat hemipituitaries incubated in vitro, thymosin alpha‑1 had no effect on growth hormone release.

    In plain wordsIn lab tests on rat pituitary tissue, thymosin alpha‑1 did not change growth hormone release.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeGrowth hormone release from hemipituitaries in vitro
    Study

    ratn: not reported in source

    Rat hemipituitaries incubated in vitro
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while there was no effect on the release of Prl and GH.
    1 context sentence
    Summary · context
    To examine if there is any direct effect of T alpha 1 at the pituitary level, we incubated hemipituitaries from male rats in vitro with different concentrations of the peptide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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