Immunohistochemical localization of delta sleep-inducing peptide-like immunoreactivity in the central nervous system and pituitary of the frog Rana ridibunda.

Yon L, Feuilloley M, Charnay Y, Vaudry H

Neuroscience1 Jan 1992Cited by 6 (Europe PMC)

PMID1315935DOI10.1016/0306-4522(92)90135-oPepBankPUB-01315935

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In perifused frog anterior pituitary cells, graded DSIP doses did not affect the spontaneous release of ACTH.
In plain wordsIn frog pituitary cells in the lab, DSIP did not change the spontaneous release of ACTH.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeSpontaneous ACTH release
Study
frog (Rana ridibunda)n: not reported in source
perifused anterior pituitary cells
Comparator
Spontaneous release
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
10(-8) to 10(-6) M · perifusion in vitroAs given in this study (frog (Rana ridibunda)).
Source sentences
Summary
Administration of graded doses of delta sleep-inducing peptide (from 10(-8) to 10(-6) M) to perifused frog anterior pituitary cells did not affect the spontaneous release of adrenocorticotropic hormone.
2 context sentences(design, population, supporting numbers)
Summary · context
The possible role of delta sleep-inducing peptide in the control of adrenocorticotropic hormone and corticosteroid release was studied in vitro, using the perifusion system technique.
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
Report a problemFND-0131593506
02LabEx vivo tissueEfficacy outcome
In perifused frog anterior pituitary cells, prolonged DSIP infusion did not alter the stimulatory effect of corticotropin-releasing factor on ACTH secretion.
In plain wordsIn frog pituitary cells in the lab, DSIP did not change how strongly corticotropin-releasing factor raised ACTH release.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeCRF-stimulated ACTH secretion
Study
frog (Rana ridibunda)n: not reported in source
perifused anterior pituitary cells
Comparator
Corticotropin-releasing factor alone
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
10(-6) M · perifusion in vitro · prolonged infusionAs given in this study (frog (Rana ridibunda)).
Source sentences
Summary
In addition, prolonged infusion of delta sleep-inducing peptide (10(-6) M) did not alter the stimulatory effect of corticotropin-releasing factor (10(-7) M) on adrenocorticotropic hormone secretion.
2 context sentences(design, population, supporting numbers)
Summary · context
The possible role of delta sleep-inducing peptide in the control of adrenocorticotropic hormone and corticosteroid release was studied in vitro, using the perifusion system technique.
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
Report a problemFND-0131593507
03LabEx vivo tissueEfficacy outcome
In frog interrenal slices, exposure to DSIP did not change spontaneous or ACTH-evoked secretion of corticosterone and aldosterone.
In plain wordsIn frog adrenal-type tissue slices in the lab, DSIP did not change corticosterone or aldosterone release.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeCorticosterone and aldosterone secretion from interrenal slices
Study
frog (Rana ridibunda)n: not reported in source
frog interrenal slices
Comparator
Spontaneous or ACTH-evoked secretion
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · in vitro exposureAs given in this study (frog (Rana ridibunda)).
Source sentences
Summary
Similarly, exposure of frog interrenal slices to delta sleep-inducing peptide did not induce any modification of spontaneous or adrenocorticotropic hormone-evoked secretion of corticosterone and aldosterone.
2 context sentences(design, population, supporting numbers)
Summary · context
The possible role of delta sleep-inducing peptide in the control of adrenocorticotropic hormone and corticosteroid release was studied in vitro, using the perifusion system technique.
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
Report a problemFND-0131593508

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04AnimalEndogenous levelAnimal study (in vivo)Other
In the frog Rana ridibunda, DSIP-like immunoreactive fibres were present throughout the brain.
In plain wordsIn frogs, the body's own DSIP-like material was found in nerve fibres throughout the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like immunoreactive fibres in the brain
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Delta sleep-inducing peptide-like immunoreactive fibres were observed throughout the brain of the frog.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593501
05AnimalEndogenous levelAnimal study (in vivo)Other
In the frog cerebellum, all Purkinje cells showed DSIP-like immunoreactivity.
In plain wordsIn frogs, natural DSIP-like material was found in all Purkinje cells of the cerebellum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like immunoreactivity in Purkinje cells
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In the cerebellum, all Purkinje cells exhibited delta sleep-inducing peptide-like immunoreactivity.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593502
06AnimalEndogenous levelAnimal study (in vivo)Other
In the frog pituitary, a dense network of DSIP-containing fibres was seen in the pars nervosa.
In plain wordsIn frogs, natural DSIP-like material was found in a dense fibre network in the back part of the pituitary.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like fibres in the pars nervosa of the pituitary
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
A dense network of delta sleep-inducing peptide-containing fibres was seen in the pars nervosa of the pituitary.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593503
07AnimalEndogenous levelAnimal study (in vivo)Other
In the frog distal pituitary lobe, a population of endocrine cells in the anteroventral region contained DSIP-immunoreactive material.
In plain wordsIn frogs, natural DSIP-like material was found in a group of hormone-producing cells in the front part of the pituitary.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like immunoreactivity in endocrine cells of the distal lobe
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In the distal lobe, a population of endocrine cells located in the anteroventral region contained delta sleep-inducing peptide-immunoreactive material.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593504
08AnimalEndogenous levelAnimal study (in vivo)Other
In the frog pituitary, a DSIP-related peptide was expressed in corticotroph cells, as shown by labelling of consecutive sections with DSIP and ACTH antiserum.
In plain wordsIn frogs, a natural DSIP-related peptide was found in the pituitary cells that make ACTH.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-related peptide in corticotroph cells
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Labelling of consecutive sections of the pituitary by delta sleep-inducing peptide and adrenocorticotropic hormone antiserum revealed that a delta sleep-inducing peptide-related peptide is expressed in corticotroph cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The purpose of the present study was to investigate the distribution of delta sleep-inducing peptide in the brain and pituitary of the frog Rana ridibunda and to determine the possible effect of this nonapeptide on adrenocorticotropic hormone and corticosteroid secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593505
09AnimalEndogenous levelAnimal study (in vivo)Other
In the frog diencephalon, numerous DSIP-containing processes were noted in the preoptic nucleus, the infundibular nuclei and the median eminence.
In plain wordsIn frogs, natural DSIP-like material was found in many nerve processes in several parts of the diencephalon.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like immunoreactive processes in the diencephalon
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In the diencephalon, numerous delta sleep-inducing peptide-containing processes were noted in the preoptic nucleus, the infundibular nuclei and the median eminence.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593509
10AnimalEndogenous levelAnimal study (in vivo)Other
In the frog mesencephalon, DSIP-positive fibres were observed radiating through the different layers of the tectum.
In plain wordsIn frogs, natural DSIP-like material was found in nerve fibres running through the layers of the midbrain tectum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-positive fibres in the mesencephalon
Study
frog (Rana ridibunda)n: not reported in source
frog brain and pituitary
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Delta sleep-inducing peptide-positive fibres were also observed in the mesencephalon, radiating through the different layers of the tectum.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0131593510

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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