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Study · Ex vivo tissue · rat · 1992

4 results

Implication of tryptophan in the stimulatory effect of delta-sleep-inducing peptide on indole secretion from perifused rat pineal glands.

Ouichou A, Pévet P

Biological signals1 Mar 1992Cited by 9 (Europe PMC)

PMID1307916 (opens in a new tab)DOI10.1159/000109313 (opens in a new tab)PepBankPUB-01307916
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP stimulated melatonin secretion in a dose-dependent manner, as tryptophan did.

    In plain wordsIn rat pineal glands in the lab, DSIP raised melatonin release, and higher doses gave more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMelatonin secretion
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we show that tryptophan (TRP), as well as DSIP, stimulate melatonin (MEL) and 5-methoxy-tryptophol (5-ML) secretion in a dose-dependent manner between 5 x 10(-6) and 10(-4) M.
  2. 02LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP stimulated 5-methoxytryptophol secretion in a dose-dependent manner, as tryptophan did.

    In plain wordsIn rat pineal glands in the lab, DSIP raised release of 5-methoxytryptophol, and higher doses gave more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Increase5-methoxytryptophol secretion
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we show that tryptophan (TRP), as well as DSIP, stimulate melatonin (MEL) and 5-methoxy-tryptophol (5-ML) secretion in a dose-dependent manner between 5 x 10(-6) and 10(-4) M.
  3. 03LabEx vivo tissueMechanism

    In perifused rat pineal glands, the increase in melatonin secretion with 10(-4) M DSIP was completely inhibited by the aminopeptidase inhibitor phenanthroline, suggesting that tryptophan liberated by peptide degradation caused the effect.

    In plain wordsIn rat pineal glands in the lab, blocking the enzyme that breaks DSIP down stopped the melatonin rise, suggesting released tryptophan caused it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP-induced melatonin secretion with phenanthroline
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increase in MEL secretion in response to 10(-4) M DSIP was completely inhibited by pretreatment of the pineals with 10(-5) M phenanthroline (amino-peptidase inhibitor), suggesting that stimulatory effect of DSIP was due to TRP liberated by peptide degradation.
  4. 04LabEx vivo tissueMechanism

    In perifused rat pineal glands, para-chlorophenylalanine, a tryptophan hydroxylase inhibitor, reduced the pineal response to 10(-4) and 10(-5) M DSIP by 50 and 100%, respectively.

    In plain wordsIn rat pineal glands in the lab, blocking tryptophan hydroxylase reduced the response to DSIP by half or fully, depending on the dose.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP-induced pineal response with para-chlorophenylalanine
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Reduction of pineal response
    50%
    10(-4) M DSIP
    Reduction of pineal response
    100%
    10(-5) M DSIP

    Source sentences

    Summary
    This mechanism occurring in the pineal was confirmed using 10(-4) M para-chlorophenylalamine (TRP hydroxylase inhibitor), which reduced the pineal response to 10(-4) and 10(-5) M DSIP by 50 and 100%, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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