[The effect of the synthetic immunomodulator thymogen on radiation-induced carcinogenesis in rats].

Anisimov VN, Miretskiĭ GI, Morozov VG, Pavel'eva IA, Khavinson VKh

Voprosy onkologii1 Jan 1992Cited by 2 (Europe PMC)

PMID1300740PepBankPUB-01300740

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female rats exposed to Sr-90 and Cs-137, thymogen decreased total tumor occurrence compared with radionuclide exposure alone.
In plain wordsIn female rats, thymogen reduced total tumor occurrence compared with radionuclide exposure alone.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseRadionuclide-induced total tumor occurrence
Study
ratn: not reported in source
female rats
Comparator
Radionuclide-treated rats without thymogen
Outcome group
Tumor growth · Cancer
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
Thymogen was shown to inhibit Sr-90- and Cs-137-induced radiation carcinogenesis, namely, a decrease in the total tumor and cancer occurrence was observed.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074001
02AnimalAnimal study (in vivo)Efficacy outcome
In female rats exposed to Sr-90 and Cs-137, thymogen decreased cancer occurrence compared with radionuclide exposure alone.
In plain wordsIn female rats, thymogen reduced cancer occurrence compared with radionuclide exposure alone.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseRadionuclide-induced cancer occurrence
Study
ratn: not reported in source
female rats
Comparator
Radionuclide-treated rats without thymogen
Outcome group
Tumor growth · Cancer
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
Thymogen was shown to inhibit Sr-90- and Cs-137-induced radiation carcinogenesis, namely, a decrease in the total tumor and cancer occurrence was observed.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074002
03AnimalAnimal study (in vivo)Efficacy outcome
In female rats, thymogen alone increased life span.
In plain wordsIn female rats, thymogen alone increased life span.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseLife span with thymogen alone
Study
ratn: not reported in source
female rats
Outcome group
Mortality · Aging and longevity
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074003
04AnimalAnimal study (in vivo)Efficacy outcome
In female rats, thymogen alone slowed aging.
In plain wordsIn female rats, thymogen alone slowed aging.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseAging rate with thymogen alone
Study
ratn: not reported in source
female rats
Outcome group
Aging markers · Aging and longevity
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074004
05AnimalAnimal study (in vivo)Efficacy outcome
In female rats, thymogen alone decreased overall tumor occurrence.
In plain wordsIn female rats, thymogen alone decreased overall tumor occurrence.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseOverall tumor occurrence with thymogen alone
Study
ratn: not reported in source
female rats
Outcome group
Tumor growth · Cancer
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074005
06AnimalAnimal study (in vivo)Efficacy outcome
In female rats, thymogen alone decreased cancer occurrence.
In plain wordsIn female rats, thymogen alone decreased cancer occurrence.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseCancer occurrence with thymogen alone
Study
ratn: not reported in source
female rats
Outcome group
Tumor growth · Cancer
Studied dose
5 micrograms/animal for 5 consecutive days per monthly course · 12 monthly coursesAs given in this study (rat).
Source sentences
Summary
The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence.
2 context sentences(design, population, supporting numbers)
Summary · context
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months.
Summary · context
Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days.
Report a problemFND-0130074006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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