Vasodilator action of guinea pig vasoactive intestinal polypeptide (VIP): comparison with common mammalian VIP.

Naruse S, Inoue T, Mochizuki T, Yanaihara N

Regulatory peptides1 Dec 1992Cited by 5 (Europe PMC)

PMID1289976DOI10.1016/0167-0115(92)90096-dPepBankPUB-01289976

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized guinea pigs, intravenous gpVIP and pVIP increased pancreatic blood flow in a dose-related manner.
In plain wordsIn guinea pigs, both forms of VIP given into a vein increased blood flow to the pancreas, more at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePancreatic blood flow
Study
guinea pign: not reported in source
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intravenousAs given in this study (guinea pig).
Source sentences
Summary
In the guinea pig, intravenous injections of gpVIP and pVIP increased pancreatic blood flow and reduced the systemic arterial pressure and pancreatic vascular resistance in a dose-related manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997601
02AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized guinea pigs, intravenous gpVIP and pVIP reduced systemic arterial pressure in a dose-related manner.
In plain wordsIn guinea pigs, both forms of VIP given into a vein lowered blood pressure, more at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSystemic arterial pressure
Study
guinea pign: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · intravenousAs given in this study (guinea pig).
Source sentences
Summary
In the guinea pig, intravenous injections of gpVIP and pVIP increased pancreatic blood flow and reduced the systemic arterial pressure and pancreatic vascular resistance in a dose-related manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997602
03AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized guinea pigs, intravenous gpVIP and pVIP reduced pancreatic vascular resistance in a dose-related manner.
In plain wordsIn guinea pigs, both forms of VIP given into a vein lowered resistance in pancreatic blood vessels, more at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreasePancreatic vascular resistance
Study
guinea pign: not reported in source
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intravenousAs given in this study (guinea pig).
Source sentences
Summary
In the guinea pig, intravenous injections of gpVIP and pVIP increased pancreatic blood flow and reduced the systemic arterial pressure and pancreatic vascular resistance in a dose-related manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997603
04AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs, the vasodilator actions of gpVIP and pVIP did not differ significantly.
In plain wordsIn guinea pigs, guinea pig VIP and common mammalian VIP widened blood vessels to a similar degree.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changegpVIP versus pVIP vasodilator action in guinea pig
Study
guinea pign: not reported in source
Comparator
pVIP
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intravenousAs given in this study (guinea pig).
Source sentences
Summary
There were no significant differences in the vasodilator actions of these two VIPs, indicating that the overall cardiovascular actions of gpVIP and pVIP are similar in guinea pigs.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997604
05AnimalAnimal study (in vivo)Efficacy outcome
In dogs, intra-arterial gpVIP was about 1/4 as potent as pVIP in its action on femoral blood flow.
In plain wordsIn dogs, guinea pig VIP was about a quarter as potent as common mammalian VIP at raising blood flow in the hind leg.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreasegpVIP versus pVIP potency on femoral blood flow in dog
Study
dogn: not reported in source
Comparator
pVIP
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
In the dog, gpVIP, when given intra-arterially, was less potent (about 1/4) than pVIP in its action on femoral blood flow, suggesting that the blood vessels of the dog hind leg are more sensitive to its own VIP than to gpVIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997605
06AnimalAnimal study (in vivo)Efficacy outcome
In dogs, oxidation of pVIP and gpVIP with H2O2 greatly reduced their vasodilator effects on femoral arterial blood flow.
In plain wordsIn dogs, oxidized VIP was much less able to raise blood flow in the hind leg than normal VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFemoral vasodilator effect of oxidized VIP
Study
dogn: not reported in source
Comparator
Unoxidized VIP
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Oxidation of pVIP and gpVIP with H2O2 greatly reduced their vasodilator effects on the femoral arterial blood flow.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997606
07AnimalAnimal study (in vivo)Mechanism
In dogs, reducing oxidized pVIP and gpVIP with mercaptoethanol restored the vascular effects to control levels, suggesting that methionine residues matter for the femoral vasodilator effect.
In plain wordsIn dogs, chemically reversing the oxidation of VIP brought back its blood-flow effect in the hind leg to normal levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRestoration of vasodilator effect by reduction of oxidized VIP
Study
dogn: not reported in source
Comparator
Oxidized VIP
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The vascular effects were restored to control levels by reduction of the oxidized peptides with mercaptoethanol, which suggests that methionine residues of gpVIP and pVIP are important in the vasodilator effect on the femoral arterial bed in dogs.
1 context sentence(design, population, supporting numbers)
Summary · context
The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs.
Report a problemFND-0128997607

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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