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Study · Animal study (in vivo) · rat · 1992

7 results

[The anticonvulsive action of the intranigral administration of the delta sleep-inducing peptide].

Shandra OA, Hodlevs'kyĭ LS, Mazarati AM, Oleshko AA, Vast'ianov RS, Mykhal'ova II

Fiziologicheskii zhurnal1 Jul 1992

PMID1286686 (opens in a new tab)PepBankPUB-01286686
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the substantia nigra reticular part suppressed generalized convulsive activity induced by picrotoxin.

    In plain wordsIn rats, DSIP injected into a brain region called the substantia nigra reduced seizures caused by picrotoxin.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePicrotoxin-induced generalized convulsive activity
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigralAs given in this study (rat).

    Source sentences

    Summary
    It is shown that injection of delta sleep-inducing peptide (DSIP) into the substantia nigra reticular part (SNrp) suppresses generalized convulsive activity induced in rats by picrotoxin and corazol injection but exerts no influence on the strichnine-induced seizures.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the substantia nigra reticular part suppressed generalized convulsive activity induced by corazol.

    In plain wordsIn rats, DSIP injected into a brain region called the substantia nigra reduced seizures caused by corazol.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCorazol-induced generalized convulsive activity
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigralAs given in this study (rat).

    Source sentences

    Summary
    It is shown that injection of delta sleep-inducing peptide (DSIP) into the substantia nigra reticular part (SNrp) suppresses generalized convulsive activity induced in rats by picrotoxin and corazol injection but exerts no influence on the strichnine-induced seizures.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the substantia nigra reticular part had no influence on strychnine-induced seizures.

    In plain wordsIn rats, DSIP injected into a brain region called the substantia nigra did not change seizures caused by strychnine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeStrychnine-induced seizures
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigralAs given in this study (rat).

    Source sentences

    Summary
    It is shown that injection of delta sleep-inducing peptide (DSIP) into the substantia nigra reticular part (SNrp) suppresses generalized convulsive activity induced in rats by picrotoxin and corazol injection but exerts no influence on the strichnine-induced seizures.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats kindled through picrotoxin injections, analogous DSIP injection had an antiepileptic action.

    In plain wordsIn rats with picrotoxin-induced kindling, DSIP injected into the same brain region had an antiepileptic action.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizures in picrotoxin-kindled rats
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigralAs given in this study (rat).

    Source sentences

    Summary
    The analogous DSIP injection causes the antiepileptic action in rats kindled through picrotoxin injections.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, naloxone blocked the intranigral anticonvulsant action of DSIP.

    In plain wordsIn rats, naloxone blocked the seizure-reducing action of DSIP injected into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP anticonvulsant action with naloxone
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The DSIP intranigral anticonvulsant action is blocked by naloxon

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, haloperidol enhanced the intranigral anticonvulsant action of DSIP.

    In plain wordsIn rats, haloperidol strengthened the seizure-reducing action of DSIP injected into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP anticonvulsant action with haloperidol
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The DSIP intranigral anticonvulsant action is blocked by naloxon and enhanced by haloperidol

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 07AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, yohimbin enhanced the intranigral anticonvulsant action of DSIP.

    In plain wordsIn rats, yohimbin strengthened the seizure-reducing action of DSIP injected into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP anticonvulsant action with yohimbin
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The DSIP intranigral anticonvulsant action is blocked by naloxon and enhanced by haloperidol and yohimbin

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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