[Effects of brain extract and hydrolysate on nerve tissue in vitro].

Lindner G, Grosse G, Matthies H, Kirsche W

Zeitschrift fur mikroskopisch-anatomische Forschung1 Jan 1975Cited by 3 (Europe PMC)

PMID1086554PepBankPUB-01086554

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, the Cerebrolysin effect depended on concentration and medium.
In plain wordsIn lab tests, the Cerebrolysin effect depended on concentration and medium.
Peptide
Cerebrolysin
Outcome
Not applicableConcentration-dependent effect
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The cerebrolysin effect is essential related to the concentration/medium.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655401
02LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, high Cerebrolysin concentrations decreased nerve fiber growth.
In plain wordsIn lab tests, high Cerebrolysin concentrations decreased nerve fiber growth.
Peptide
Cerebrolysin
Outcome
DecreaseNerve fiber growth
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
High concentrationAs given in this study (chick embryos or fetal rats).
Source sentences
Summary
High concentration of cerebrolysin decreases the growth of nerve fibers.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655402
03LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin increased non-neuronal cell migration.
In plain wordsIn lab tests, Cerebrolysin increased movement of non-neuronal cells.
Peptide
Cerebrolysin
Outcome
IncreaseNon-neuronal cell migration
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Migration of non-neuronal cells increases.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655403
04LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin did not show NGF-like stimulation of nerve fiber growth.
In plain wordsIn lab tests, Cerebrolysin did not stimulate nerve fiber growth like NGF.
Peptide
Cerebrolysin
Outcome
No significant changeNGF-like nerve fiber growth stimulation
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A stimulation of nerve fibers growth resembling to NGF was not seen.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655404
05LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin changed cell density.
In plain wordsIn lab tests, Cerebrolysin changed cell density.
Peptide
Cerebrolysin
Outcome
Direction not reportedCell density
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The density of cells or number of cells/volume unit, rate of mitosis and phases of mitotic non-neuronal cells is changed by cerebrolysin.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655405
06LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin changed the mitosis rate.
In plain wordsIn lab tests, Cerebrolysin changed the rate of cell division.
Peptide
Cerebrolysin
Outcome
Direction not reportedMitosis rate
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The density of cells or number of cells/volume unit, rate of mitosis and phases of mitotic non-neuronal cells is changed by cerebrolysin.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655406
07LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin changed mitotic phases of non-neuronal cells.
In plain wordsIn lab tests, Cerebrolysin changed cell division phases in non-neuronal cells.
Peptide
Cerebrolysin
Outcome
Direction not reportedMitotic phases of non-neuronal cells
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The density of cells or number of cells/volume unit, rate of mitosis and phases of mitotic non-neuronal cells is changed by cerebrolysin.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655407
08LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, Cerebrolysin effects resembled those of the tested amino acid solution and brain extract.
In plain wordsIn lab tests, Cerebrolysin effects resembled those of the amino acid solution and brain extract.
Peptide
Cerebrolysin
Outcome
Not applicableComparative tissue culture effect
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Comparator
Tested amino acid solution and brain extract
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The effect of cerebrolysin in vitro is compared to the tested aminoacidsolution and brainextract resembling.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655408
09LabEx vivo tissueActivity measurement
In chick embryo or fetal rat explants, the Cerebrolysin effect depended only slightly on the preparation batch (termed charge).
In plain wordsIn lab tests, the Cerebrolysin effect depended only slightly on the preparation batch.
Peptide
Cerebrolysin
Outcome
Not applicablePreparation-dependent effect
Study
chick embryos or fetal ratsn: not reported in source
PNS and CNS explant cultures
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin exercised in vitro an effect, which is related to charge only trifling.
1 context sentence(design, population, supporting numbers)
Summary · context
Explants of PNS and CNS of chick embryos or fetal rats were cultivated and brainhydrolysat cerebrolysin or a synthetic aminoacidsolution or a brain extrakt was applied to the cultures.
Report a problemFND-0108655409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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