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Study · Animal study (in vivo) · mouse · 1976

3 results

Thymic function in NZB mice. II. Regulatory influence of a circulating thymic factor on antibody production against polyvinylpyrrolidone in NZB mice.

Bach MA, Niaudet P

Journal of immunology (Baltimore, Md. : 1950)1 Sept 1976Cited by 34 (Europe PMC)

PMID1085309 (opens in a new tab)PepBankPUB-01085309
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young NZB mice, circulating thymic factor prevented exaggerated anti-PVP antibody production.

    In plain wordsIn young NZB mice, circulating thymic factor prevented excessive antibody production against PVP.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseExaggerated anti-PVP antibody production in young mice
    Study

    mousen: not reported in source

    NZB mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of a circulating thymic factor isolated from normal pig blood prevented the development of the exaggerated production of anti-polyvinyl pyrrolidone (PVP) antibody in young NZB mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In NZB mice, thymic factor treatment was ineffective when initiated after the fourth week of life.

    In plain wordsIn NZB mice, thymic factor did not prevent excessive antibody production when treatment started after the fourth week.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeAnti-PVP antibody production with treatment after the fourth week
    Study

    mousen: not reported in source

    NZB mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, treatment was ineffective if initiated after the 4th week of life at a time when endogenous serum thymic factor (TF) normally disappears in these mice.
    1 context sentence
    Summary · context
    Administration of a circulating thymic factor isolated from normal pig blood prevented the development of the exaggerated production of anti-polyvinyl pyrrolidone (PVP) antibody in young NZB mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In older NZB mice, thymic factor treatment increased anti-PVP antibody production.

    In plain wordsIn older NZB mice, thymic factor increased antibody production against PVP.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAnti-PVP antibody production in older mice
    Study

    mousen: not reported in source

    NZB mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In older NZB mice, TF treatment increased paradoxically anti-PVP antibody production

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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