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Study · Non-randomized trial · n = 6 · 1976

8 results

Absorption of inorganic phosphate in the human jejunum and its inhibition by salmon calcitonin.

Juan D, Liptak P, Gray TK

The Journal of clinical endocrinology and metabolism1 Sept 1976Cited by 15 (Europe PMC)

PMID986400 (opens in a new tab)DOI10.1210/jcem-43-3-517 (opens in a new tab)PepBankPUB-00986400
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin induced net jejunal water secretion, whereas saline did not affect absorption.

    In plain wordsIn normal subjects, salmon calcitonin caused intestinal water secretion, while saline did not affect absorption.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseJejunal water secretion
    Study

    n = 6

    Comparator
    Saline infusion
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    A net secretion of water and electrolytes occurred in six normal subjects given SCT (250 ng/kg/hr) while saline infusion instead of SCT had no effect on jejunal absorption.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  2. 02HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin induced net jejunal electrolyte secretion, whereas saline did not affect absorption.

    In plain wordsIn normal subjects, salmon calcitonin caused intestinal electrolyte secretion, while saline did not affect absorption.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseJejunal electrolyte secretion
    Study

    n = 6

    Comparator
    Saline infusion
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    A net secretion of water and electrolytes occurred in six normal subjects given SCT (250 ng/kg/hr) while saline infusion instead of SCT had no effect on jejunal absorption.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  3. 03HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin reduced jejunal calcium absorption by 58% from basal conditions.

    In plain wordsIn normal subjects, salmon calcitonin reduced intestinal calcium absorption by 58% from basal conditions.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseCalcium absorption
    Study

    n = 6

    Comparator
    Basal conditions
    Outcome group
    Mineral metabolism · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Measurements

    Calcium absorption reduction
    58%

    Source sentences

    Summary
    Along with the secretory effect SCT reduced calcium and P absorption by 58% and 62% respectively, without any significant fall in the serum levels of calcium or P.
    2 context sentences
    Summary · context
    A net secretion of water and electrolytes occurred in six normal subjects given SCT (250 ng/kg/hr) while saline infusion instead of SCT had no effect on jejunal absorption.
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  4. 04HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin reduced jejunal phosphate absorption by 62% from basal conditions.

    In plain wordsIn normal subjects, salmon calcitonin reduced intestinal phosphate absorption by 62% from basal conditions.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreasePhosphate absorption
    Study

    n = 6

    Comparator
    Basal conditions
    Outcome group
    Mineral metabolism · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Measurements

    Phosphate absorption reduction
    62%

    Source sentences

    Summary
    Along with the secretory effect SCT reduced calcium and P absorption by 58% and 62% respectively, without any significant fall in the serum levels of calcium or P.
    2 context sentences
    Summary · context
    A net secretion of water and electrolytes occurred in six normal subjects given SCT (250 ng/kg/hr) while saline infusion instead of SCT had no effect on jejunal absorption.
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  5. 05HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin did not significantly lower serum calcium during the jejunal response.

    In plain wordsIn normal subjects, salmon calcitonin did not significantly lower blood calcium during the intestinal response.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeSerum calcium
    Study

    n = 6

    Outcome group
    Mineral metabolism · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Along with the secretory effect SCT reduced calcium and P absorption by 58% and 62% respectively, without any significant fall in the serum levels of calcium or P.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  6. 06HumanNon-randomized trialMechanism

    In normal subjects, salmon calcitonin did not significantly lower serum phosphate during the jejunal response.

    In plain wordsIn normal subjects, salmon calcitonin did not significantly lower blood phosphate during the intestinal response.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeSerum phosphate
    Study

    n = 6

    Outcome group
    Mineral metabolism · Gastrointestinal
    Studied dose
    250 ng/kg/hr · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Along with the secretory effect SCT reduced calcium and P absorption by 58% and 62% respectively, without any significant fall in the serum levels of calcium or P.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  7. 07HumanNon-randomized trialMechanism

    In a hypoparathyroid subject, the jejunal response to salmon calcitonin was reproduced twice, supporting independence from endogenous parathyroid hormone.

    In plain wordsIn a subject with low parathyroid function, the intestinal response to salmon calcitonin occurred twice without endogenous parathyroid hormone involvement.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableJejunal response without endogenous PTH
    Study

    n = 1

    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    The jejunal response to SCT was reproduced twice in a hypoparathyroid subject showing that endogenous parathyroid hormone was not involved in this effect.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.
  8. 08HumanNon-randomized trialMechanism

    In subjects studied during salmon calcitonin infusion, calcium and phosphate absorption correlated positively with water movement.

    In plain wordsIn subjects studied during salmon calcitonin infusion, intestinal calcium and phosphate absorption correlated positively with water movement.

    Peptide
    Calcitonin-salmon
    Outcome
    Not applicableCalcium and phosphate absorption correlated with water movement
    Study

    n: not reported in source

    Outcome group
    Mineral metabolism · Gastrointestinal
    Studied dose
    Dose not stated · intravenous infusionAs given in this study (human).

    Source sentences

    Summary
    Calcium and P absorption were positively correlated with water movement suggesting that the observed changes in calcium and P absorption are due primarily to SCT-induced secretion of water.
    1 context sentence
    Summary · context
    The jejunal absorption of inorganic phosphate (P) was studied under basal conditions and during the intravenous infusion of synthetic salmon calcitonin (SCT) in normal subjects.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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