Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells.

Dannies PS, Yen PM, Tashijian AH Jr

Endocrinology1 Oct 1977Cited by 21 (Europe PMC)

PMID908269DOI10.1210/endo-101-4-1151PepBankPUB-00908269

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In rat pituitary GH-cells, enclomiphene increased prolactin synthesis after one week.
In plain wordsIn cells from rat pituitaries, enclomiphene increased prolactin production after one week.
Peptide
Enclomiphene
Outcome
IncreaseProlactin synthesis
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
About 10(-7) to 10(-6)M · one weekAs given in this study (rat).
Source sentences
Summary
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
Report a problemFND-0090826901
02LabIn vitro (cells)Mechanism
In rat pituitary GH-cells, enclomiphene increased growth hormone synthesis after one week.
In plain wordsIn cells from rat pituitaries, enclomiphene increased growth hormone production after one week.
Peptide
Enclomiphene
Outcome
IncreaseGrowth hormone synthesis
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
About 10(-7) to 10(-6)M · one weekAs given in this study (rat).
Source sentences
Summary
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
Report a problemFND-0090826902
03LabIn vitro (cells)Mechanism
In rat pituitary GH-cells, prolactin synthesis remained elevated for at least 11 days after enclomiphene removal.
In plain wordsIn cells from rat pituitaries, prolactin production remained elevated for at least 11 days after enclomiphene removal.
Peptide
Enclomiphene
Outcome
IncreasePersistent prolactin synthesis after withdrawal
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · At least 11 days after removalAs given in this study (rat).
Source sentences
Summary
Prolactin synthesis remained elevated for at least 11 days after removal of enclomiphene from the culture medium but, in the presence of estradiol, synthesis approached control levels by 11 days.
1 context sentence(design, population, supporting numbers)
Summary · context
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
Report a problemFND-0090826905

Studies that did not test the peptide alone3

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

04LabNot a test of Enclomiphene aloneIn vitro (cells)Mechanism
In rat pituitary GH-cells, estradiol prevented the prolactin synthesis increase induced by antiestrogens including enclomiphene.
In plain wordsIn cells from rat pituitaries, estradiol prevented the prolactin increase induced by antiestrogens including enclomiphene.
Peptide
Enclomiphene
Outcome
DecreaseEstradiol prevention of prolactin increase
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
These increases were prevented by 10(-8)M 17beta-estradiol.
1 context sentence(design, population, supporting numbers)
Summary · context
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0090826903
05LabNot a test of Enclomiphene aloneIn vitro (cells)Mechanism
In rat pituitary GH-cells, estradiol prevented the growth hormone synthesis increase induced by antiestrogens including enclomiphene.
In plain wordsIn cells from rat pituitaries, estradiol prevented the growth hormone increase induced by antiestrogens including enclomiphene.
Peptide
Enclomiphene
Outcome
DecreaseEstradiol prevention of growth hormone increase
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
These increases were prevented by 10(-8)M 17beta-estradiol.
1 context sentence(design, population, supporting numbers)
Summary · context
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0090826904
06LabNot a test of Enclomiphene aloneIn vitro (cells)Mechanism
In rat pituitary GH-cells after enclomiphene removal, estradiol brought prolactin synthesis toward control levels by 11 days.
In plain wordsIn cells from rat pituitaries, estradiol brought prolactin production toward control levels after enclomiphene removal.
Peptide
Enclomiphene
Outcome
DecreaseProlactin synthesis with estradiol after withdrawal
Study
ratn: not reported in source
Clonal rat pituitary GH-cells
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Prolactin synthesis remained elevated for at least 11 days after removal of enclomiphene from the culture medium but, in the presence of estradiol, synthesis approached control levels by 11 days.
1 context sentence(design, population, supporting numbers)
Summary · context
Unexpectedly, the estrogen antagonists enclomiphene, CI-628, tamoxifen, and Lilly 88751 caused increases in both prolactin and growth hormone synthesis at concentrations of about 10(-7) to 10(-6)M after one week of treatment.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0090826906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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