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Study · Animal study (in vivo) · rabbit · 1977

1 result

Synthesis of the tripeptide L-Trp-L-Ser-L-Glu. Comparison of its biological activity with that of the delta-sleep-inducing-peptide (DSIP).

Monnier VM

Experientia. Supplementum1 Jan 1977Cited by 5 (Europe PMC)

PMID891716 (opens in a new tab)PepBankPUB-00891716
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rabbits, intraventricular DSIP induced a marked increase of delta EEG activity, which the tripeptide Trp-Ser-Glu could not duplicate.

    In plain wordsIn rabbits, DSIP given into the brain ventricles markedly raised delta brain-wave activity, unlike the tested three-amino-acid peptide.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseEEG delta activity after DSIP versus tripeptide Trp-Ser-Glu
    Study

    rabbitn: not reported in source

    Comparator
    Tripeptide L-Trp-L-Ser-L-Glu
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated · intraventricular infusionAs given in this study (rabbit).

    Source sentences

    Summary
    The effects of the tripeptide on the EEG could not duplicate those of DSIP which induced a marked increase of delta activity, typical for orthodox 'Slow Wave Sleep' (SWS).
    1 context sentence
    Summary · context
    The biological activity of the tripeptide was assayed by intraventricular infusion in the rabbit under the same conditions as for the DSIP.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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