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Study · Not a test of the peptide alone · 1977

4 results

Quantitative analysis of nonapeptides in pharmaceutical dosage forms by high-performance liquid chromatography.

Krummen K, Frei RW

Journal of chromatography1 Feb 1977Cited by 29 (Europe PMC)

PMID885943 (opens in a new tab)DOI10.1016/s0021-9673(00)82907-6 (opens in a new tab)PepBankPUB-00885943
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    The HPLC method accurately determined oxytocin in injection solutions containing 1 I.U. per ml using injection volumes up to 750 microliter.

    In plain wordsIn lab testing, the HPLC method measured low-concentration oxytocin in injection solutions.

    Peptide
    Oxytocin
    Outcome
    Not applicableHPLC determination of oxytocin in injection solutions
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    Oxytocin concentration
    1 I.U. (international unit) per ml
    injection solutions
    Injection volume
    ≤ 750 microliter
    injection volume

    Source sentences

    Summary
    The use of injection volumes up to 750 microliter permits accurate determination of, e.g., oxytocin in injection solutions containing only 1 I.U. (international unit) per ml.
    1 context sentence
    Summary · context
    A high-performance liquid chromatographic (HPLC) method is described for determining oxytocin, lypressin and other nonapeptides and their by-products in liquid and solid pharmaceutical dosage forms.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    For liquid pharmaceutical dosage forms of nonapeptides, including oxytocin, the HPLC method had reproducibility between 1.0 and 1.5% relative S.D.

    In plain wordsIn lab tests of liquid nonapeptide dosage forms including oxytocin, HPLC reproducibility was 1.0 to 1.5% relative S.D.

    Peptide
    Oxytocin
    Outcome
    Not applicableHPLC reproducibility in liquid dosage forms
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    Reproducibility
    1 to 1.5 % (relative S.D)
    liquid dosage forms

    Source sentences

    Summary
    Reproducibilities between 1.0 and 1.5% (relative S.D) have been obtained for liquid dosage forms and up to 3% (relative S.D.) for tablets.
    1 context sentence
    Summary · context
    A high-performance liquid chromatographic (HPLC) method is described for determining oxytocin, lypressin and other nonapeptides and their by-products in liquid and solid pharmaceutical dosage forms.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    For tablet pharmaceutical dosage forms of nonapeptides, including oxytocin, the HPLC method had reproducibility up to 3% relative S.D.

    In plain wordsIn lab tests of nonapeptide tablets including oxytocin, HPLC reproducibility was up to 3% relative S.D.

    Peptide
    Oxytocin
    Outcome
    Not applicableHPLC reproducibility in tablets
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    Reproducibility
    ≤ 3 % (relative S.D.)
    tablets

    Source sentences

    Summary
    Reproducibilities between 1.0 and 1.5% (relative S.D) have been obtained for liquid dosage forms and up to 3% (relative S.D.) for tablets.
    1 context sentence
    Summary · context
    A high-performance liquid chromatographic (HPLC) method is described for determining oxytocin, lypressin and other nonapeptides and their by-products in liquid and solid pharmaceutical dosage forms.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    For pharmaceutical dosage forms of nonapeptides, including oxytocin, HPLC and bioassay results were highly significantly correlated.

    In plain wordsIn lab tests of nonapeptide dosage forms including oxytocin, HPLC and bioassay results were highly significantly correlated.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of HPLC with bioassay
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    The correlation between results obtained by bioassay and by the proposed method is highly significant and suggests the use of HPLC as an alternative technique for stability and content-uniformity tests on dosage forms and concentrates.
    1 context sentence
    Summary · context
    A high-performance liquid chromatographic (HPLC) method is described for determining oxytocin, lypressin and other nonapeptides and their by-products in liquid and solid pharmaceutical dosage forms.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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