Use of calcitonin in psychotic agitation or mania.

Carman JS, Wyatt RJ

Archives of general psychiatry1 Jan 1979Cited by 26 (Europe PMC)

PMID760698DOI10.1001/archpsyc.1979.01780010078008PepBankPUB-00760698

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In psychiatric inpatients, salmon calcitonin decreased serum calcium in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, salmon calcitonin decreased blood calcium in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
DecreaseSerum calcium
Study
n = 12
Comparator
Placebo
Outcome group
Mineral metabolism · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
1 context sentence(design, population, supporting numbers)
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069801
02HumanNon-randomized trialEfficacy outcome
In psychiatric inpatients, salmon calcitonin decreased serum phosphorus in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, salmon calcitonin decreased blood phosphorus in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
DecreaseSerum phosphorus
Study
n = 12
Comparator
Placebo
Outcome group
Mineral metabolism · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
1 context sentence(design, population, supporting numbers)
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069802
03HumanNon-randomized trialEfficacy outcome
In psychiatric inpatients, salmon calcitonin increased CSF calcium in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, salmon calcitonin increased calcium in cerebrospinal fluid in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
IncreaseCSF calcium
Study
n = 12
Comparator
Placebo
Outcome group
Mineral metabolism · Nervous system and cognition
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
1 context sentence(design, population, supporting numbers)
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069803
04HumanNon-randomized trialSafety outcome
In psychiatric inpatients, salmon calcitonin appeared to increase depression transiently for 24 hours in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, salmon calcitonin appeared to increase depression temporarily in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
IncreaseDepression
Study
n = 12
Comparator
Placebo
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
1 context sentence(design, population, supporting numbers)
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069804
05HumanNon-randomized trialEfficacy outcome
In psychiatric inpatients, salmon calcitonin appeared to reduce arousal transiently for 24 hours, supported by activity monitoring in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, salmon calcitonin appeared to reduce arousal for 24 hours in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
DecreaseArousal and activity
Study
n = 12
Comparator
Placebo
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
2 context sentences(design, population, supporting numbers)
Summary · context
Quantitative activity monitoring confirmed the rater's impression that this agent had tranquilizing or depressant effects in such patients.
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069805
06HumanNon-randomized trialEfficacy outcome
In psychiatric inpatients, evening salmon calcitonin appeared to delay sleep onset in a placebo-controlled trial.
In plain wordsIn psychiatric inpatients, evening salmon calcitonin appeared to delay sleep onset in a trial with placebo.
Peptide
Calcitonin-salmon
Outcome
IncreaseSleep onset
Study
n = 12
Comparator
Placebo
Outcome group
Sleep · Sleep
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
When given in the evening, this polypeptide also appeared to delay sleep onset, as demonstrated both by nurses' 30-minute sleep checks and by the same longitudinal activity record.
2 context sentences(design, population, supporting numbers)
Summary · context
By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial.
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069806
07HumanNon-randomized trialEfficacy outcome
In agitated patients, the hypocalcemic response to salmon calcitonin was decreased.
In plain wordsIn agitated patients, salmon calcitonin produced a decreased calcium-lowering response.
Peptide
Calcitonin-salmon
Outcome
DecreaseHypocalcemic response in agitation
Study
n: not reported in source
Outcome group
Mineral metabolism · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Source sentences
Summary
A decreased hypocalcemic response to calcitonin was noted in the agitated patients, which might explain the increases in serum calcium level described at the "switch".
1 context sentence(design, population, supporting numbers)
Summary · context
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses.
Report a problemFND-0076069807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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