The adrenergic influences on the hypothalamic and neurohypophysial oxytocic activity in long-term dehydrated male white rats.

Guzek JW, Swiderska Z, Motylewska A

Acta physiologica Polonica1 May 1978Cited by 5 (Europe PMC)

PMID707140PepBankPUB-00707140

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In nondehydrated rats, phenoxybenzamine decreased endogenous hypothalamic oxytocin content.
In plain wordsIn nondehydrated rats, phenoxybenzamine lowered the body's own hypothalamic oxytocin content.
Peptide
Oxytocin
Outcome
DecreaseHypothalamic oxytocin content in nondehydrated rats after phenoxybenzamine
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated animals, both drugs decreased significantly the hypothalamic and neurohypophysial oxytocin content.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats dehydrated up to 12 days were given intraperitoneally phenoxybenzamine hydrochloride or amphetamine sulfate in daily doses of 0.2 mg/100 g or 0.5 mg/100 g, respectively.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714001
02AnimalEndogenous levelAnimal study (in vivo)Other
In dehydrated rats, endogenous oxytocin activity in the hypothalamo-neurohypophysial system progressively diminished.
In plain wordsIn dehydrated rats, the body's own oxytocin activity progressively fell.
Peptide
Oxytocin
Outcome
DecreaseHypothalamo-neurohypophysial oxytocin activity during dehydration
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In dehydrated rats the oxytocin activity in the hypothalamo-neurohypophysial system diminished progressively
1 context sentence(design, population, supporting numbers)
Summary · context
Rats dehydrated up to 12 days were given intraperitoneally phenoxybenzamine hydrochloride or amphetamine sulfate in daily doses of 0.2 mg/100 g or 0.5 mg/100 g, respectively.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714002
03AnimalEndogenous levelAnimal study (in vivo)Other
In dehydrated rats, as endogenous hypothalamo-neurohypophysial oxytocin activity diminished progressively, phenoxybenzamine potentiated the effects of osmoreceptor stimulation.
In plain wordsIn dehydrated rats, phenoxybenzamine potentiated osmoreceptor stimulation as the body's own oxytocin activity progressively fell.
Peptide
Oxytocin
Outcome
Direction not reportedAdrenergic modulation of hypothalamo-neurohypophysial oxytocin activity by phenoxybenzamine during dehydration
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
dehydrated rats the oxytocin activity in the hypothalamo-neurohypophysial system diminished progressively; under such conditions, inhibition of alpha-adrenergic receptors (brought about by using phenoxybenzamine as pharmacological tool) as well as the stimulation of the alpha- and beta-adrenergic re…
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714003
04AnimalEndogenous levelAnimal study (in vivo)Other
In nondehydrated rats, amphetamine decreased endogenous hypothalamic oxytocin content.
In plain wordsIn nondehydrated rats, amphetamine lowered the body's own hypothalamic oxytocin content.
Peptide
Oxytocin
Outcome
DecreaseHypothalamic oxytocin content in nondehydrated rats after amphetamine
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated animals, both drugs decreased significantly the hypothalamic and neurohypophysial oxytocin content.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats dehydrated up to 12 days were given intraperitoneally phenoxybenzamine hydrochloride or amphetamine sulfate in daily doses of 0.2 mg/100 g or 0.5 mg/100 g, respectively.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714004
05AnimalEndogenous levelAnimal study (in vivo)Other
In nondehydrated rats, phenoxybenzamine decreased endogenous neurohypophysial oxytocin content.
In plain wordsIn nondehydrated rats, phenoxybenzamine lowered the body's own neurohypophysial oxytocin content.
Peptide
Oxytocin
Outcome
DecreaseNeurohypophysial oxytocin content in nondehydrated rats after phenoxybenzamine
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated animals, both drugs decreased significantly the hypothalamic and neurohypophysial oxytocin content.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats dehydrated up to 12 days were given intraperitoneally phenoxybenzamine hydrochloride or amphetamine sulfate in daily doses of 0.2 mg/100 g or 0.5 mg/100 g, respectively.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714005
06AnimalEndogenous levelAnimal study (in vivo)Other
In nondehydrated rats, amphetamine decreased endogenous neurohypophysial oxytocin content.
In plain wordsIn nondehydrated rats, amphetamine lowered the body's own neurohypophysial oxytocin content.
Peptide
Oxytocin
Outcome
DecreaseNeurohypophysial oxytocin content in nondehydrated rats after amphetamine
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated animals, both drugs decreased significantly the hypothalamic and neurohypophysial oxytocin content.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats dehydrated up to 12 days were given intraperitoneally phenoxybenzamine hydrochloride or amphetamine sulfate in daily doses of 0.2 mg/100 g or 0.5 mg/100 g, respectively.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714006
07AnimalEndogenous levelAnimal study (in vivo)Other
In dehydrated rats, as endogenous hypothalamo-neurohypophysial oxytocin activity diminished progressively, amphetamine potentiated the effects of osmoreceptor stimulation.
In plain wordsIn dehydrated rats, amphetamine potentiated osmoreceptor stimulation as the body's own oxytocin activity progressively fell.
Peptide
Oxytocin
Outcome
Direction not reportedAdrenergic modulation of hypothalamo-neurohypophysial oxytocin activity by amphetamine during dehydration
Study
ratn: not reported in source
hypothalamo-neurohypophysial system
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
dehydrated rats the oxytocin activity in the hypothalamo-neurohypophysial system diminished progressively; under such conditions, inhibition of alpha-adrenergic receptors (brought about by using phenoxybenzamine as pharmacological tool) as well as the stimulation of the alpha- and beta-adrenergic re…
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0070714007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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