Comparative effects of synthetic and natural vasoactive intestinal peptide on pancreatic and biliary secretion and on glucose and insulin blood levels in the dog.

Makhlouf GM, Yau WM, Zfass AM, Said SI, Bodanszky M

Scandinavian journal of gastroenterology1 Jan 1978Cited by 14 (Europe PMC)

PMID694415DOI10.3109/00365527809181792PepBankPUB-00694415

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP was a partial agonist of pancreatic secretion, with efficacy 0.27 relative to secretin.
In plain wordsIn dogs, synthetic VIP stimulated pancreatic secretion weakly compared with secretin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePancreatic secretion efficacy relative to secretin
Study
dogn: not reported in source
Comparator
Secretin
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Measurements
Efficacy relative to secretin
0.27 ratio
pancreatic secretion
Source sentences
Summary
Synthetic VIP was a secretin-like partial agonist of pancreatic and biliary secretion with efficacies relative to secretin of 0.27 and 0.41, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441501
02AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP was a partial agonist of biliary secretion, with efficacy 0.41 relative to secretin.
In plain wordsIn dogs, synthetic VIP stimulated bile secretion weakly compared with secretin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBiliary secretion efficacy relative to secretin
Study
dogn: not reported in source
Comparator
Secretin
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Measurements
Efficacy relative to secretin
0.41 ratio
biliary secretion
Source sentences
Summary
Synthetic VIP was a secretin-like partial agonist of pancreatic and biliary secretion with efficacies relative to secretin of 0.27 and 0.41, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441502
03AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP augmented the pancreatic response to CCK-OP.
In plain wordsIn dogs, synthetic VIP increased the pancreas response to CCK-OP compared with CCK-OP alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePancreatic response to CCK-OP
Study
dogn: not reported in source
Comparator
CCK-OP alone
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
synthetic VIP augmented the pancreatic response to CCK-OP
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441503
04AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP augmented the submaximal pancreatic response to secretin.
In plain wordsIn dogs, synthetic VIP increased the pancreas response to a low dose of secretin compared with secretin alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePancreatic response to submaximal secretin
Study
dogn: not reported in source
Comparator
Secretin alone
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
synthetic VIP augmented the pancreatic response to CCK-OP and the submaximal but not the maximal response to secretin
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441504
05AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP did not augment the maximal pancreatic response to secretin.
In plain wordsIn dogs, synthetic VIP did not increase the pancreas response to a maximal dose of secretin compared with secretin alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePancreatic response to maximal secretin
Study
dogn: not reported in source
Comparator
Secretin alone
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
synthetic VIP augmented the pancreatic response to CCK-OP and the submaximal but not the maximal response to secretin
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441505
06AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP produced a dose-dependent increase in blood glucose levels.
In plain wordsIn dogs, synthetic VIP raised blood glucose, and a higher dose raised it more.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBlood glucose level
Study
dogn: not reported in source
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Synthetic VIP also produced a dose-dependent increase in blood glucose levels and a synchronous and proportionate increase in blood insulin levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441506
07AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP produced a synchronous and proportionate increase in blood insulin levels.
In plain wordsIn dogs, synthetic VIP raised blood insulin in step with blood glucose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBlood insulin level
Study
dogn: not reported in source
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
a synchronous and proportionate increase in blood insulin levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441507
08AnimalAnimal study (in vivo)Efficacy outcome
In dogs, synthetic VIP produced a slight increase in total calcium levels that was equivocal.
In plain wordsIn dogs, synthetic VIP gave a slight calcium rise, but the result was not clear.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeTotal blood calcium level
Study
dogn: not reported in source
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
A slight increase in total calcium levels was equivocal.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441508
09AnimalAnimal study (in vivo)Efficacy outcome
In dogs, natural porcine VIP had effects on pancreatic and biliary secretion and on glucose and insulin blood levels that were identical to those of synthetic VIP.
In plain wordsIn dogs, natural VIP had the same effects as synthetic VIP on secretion, glucose and insulin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableNatural porcine VIP effects on secretion, glucose and insulin versus synthetic VIP
Study
dogn: not reported in source
Comparator
Synthetic VIP
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
The effects of antural VIP on pancreatic and biliary secretion and on glucose and insulin blood levels were identical to those of synthetic VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP.
Report a problemFND-0069441509

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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