Comparison of firing patterns in oxytocin- and vasopressin-releasing neurones during progressive dehydration.

Wakerley JB, Poulain DA, Brown D

Brain research1 Jun 1978Cited by 170 (Europe PMC)

PMID656941DOI10.1016/0006-8993(78)90730-8PepBankPUB-00656941

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement
In lactating rats, dehydration increased firing in cells classified as oxytocin neurons from 0.9 to 2.8 spikes/sec after 24 h.
In plain wordsIn lactating rats, dehydration increased firing in cells classified as oxytocin neurons from 0.9 to 2.8 spikes/sec after 24 h.
Peptide
Oxytocin
Outcome
IncreaseOxytocin neuron firing rate during dehydration
Study
ratn: not reported in source
urethane-anaesthetized lactating rats
Comparator
baseline
Outcome group
Brain and neuronal activity · Nervous system and cognition
Measurements
Firing rate
0.9 spikes/sec
0 h
Firing rate
2.8 spikes/sec
24 h
Source sentences
Summary
In 77 identified oxytocin units, dehydration increased the firing rate from 0.9 spikes/sec to 2.8 spikes/sec after 24 h, but only 3 (4%) of the cells showed phasic firing.
1 context sentence(design, population, supporting numbers)
Summary · context
The electrical activity of neurosecretory cells in the supraoptic nucleus of the urethane-anaesthetized lactating rat was examined after periods of water deprivation ranging from 0-24 h. Supraoptic units were identified by antidromic activation following stimulation of the neurohypophysis, and class…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0065694101
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement
In lactating rats, 3 of 77 cells classified as oxytocin neurons (4%) showed phasic firing during dehydration.
In plain wordsIn lactating rats, 3 of 77 cells classified as oxytocin neurons (4%) showed phasic firing during dehydration.
Peptide
Oxytocin
Outcome
Not applicablePhasic firing of oxytocin neurons during dehydration
Study
ratn: not reported in source
urethane-anaesthetized lactating rats
Outcome group
Brain and neuronal activity · Nervous system and cognition
Measurements
Oxytocin units with phasic firing
3 cells
during dehydration
Oxytocin units with phasic firing
4%
during dehydration
Source sentences
Summary
In 77 identified oxytocin units, dehydration increased the firing rate from 0.9 spikes/sec to 2.8 spikes/sec after 24 h, but only 3 (4%) of the cells showed phasic firing.
1 context sentence(design, population, supporting numbers)
Summary · context
The electrical activity of neurosecretory cells in the supraoptic nucleus of the urethane-anaesthetized lactating rat was examined after periods of water deprivation ranging from 0-24 h. Supraoptic units were identified by antidromic activation following stimulation of the neurohypophysis, and class…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0065694102
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement
In lactating rats, cells classified as oxytocin neurons changed from slow irregular to fast continuous firing during dehydration.
In plain wordsIn lactating rats, cells classified as oxytocin neurons changed from slow irregular to fast continuous firing during dehydration.
Peptide
Oxytocin
Outcome
IncreaseOxytocin neuron discharge pattern during dehydration
Study
ratn: not reported in source
urethane-anaesthetized lactating rats
Comparator
baseline
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
Instead, the oxytocin units changed from a slow irregular to a fast continuous discharge.
1 context sentence(design, population, supporting numbers)
Summary · context
The electrical activity of neurosecretory cells in the supraoptic nucleus of the urethane-anaesthetized lactating rat was examined after periods of water deprivation ranging from 0-24 h. Supraoptic units were identified by antidromic activation following stimulation of the neurohypophysis, and class…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0065694103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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