Skip to content

Study · Animal study (in vivo) · rabbit · 1977

3 results

Transport of the synthetic peptide DSIP through the blood-brain barrier in rabbit.

Monnier M, Dudler L, Gächter R, Schoenenberger GA

Experientia1 Dec 1977Cited by 10 (Europe PMC)

PMID590449 (opens in a new tab)DOI10.1007/bf01934026 (opens in a new tab)PepBankPUB-00590449
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, intravenous DSIP passed the blood-brain barrier, as shown by its central effects.

    In plain wordsIn rabbits, DSIP given into a vein reached the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablePassage of DSIP through the blood-brain barrier
    Study

    rabbitn: not reported in source

    Free-moving rabbits
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    30 nmoles/kg · intravenous · 5 hAs given in this study (rabbit).

    Source sentences

    Summary
    The synthetic delta sleep inducing peptide (DSIP) passes the blood-brain barrier, since i.v. injection in free moving rabbits (30 nmoles/kg) significantly increases the cortical delta activity and decreases the motor activity during 5 h.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In free-moving rabbits, intravenous DSIP significantly increased cortical delta activity over 5 hours.

    In plain wordsIn rabbits, DSIP given into a vein raised slow-wave brain activity for 5 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCortical delta activity
    Study

    rabbitn: not reported in source

    Free-moving rabbits
    Outcome group
    Sleep · Sleep
    Studied dose
    30 nmoles/kg · intravenous · 5 hAs given in this study (rabbit).

    Source sentences

    Summary
    The synthetic delta sleep inducing peptide (DSIP) passes the blood-brain barrier, since i.v. injection in free moving rabbits (30 nmoles/kg) significantly increases the cortical delta activity and decreases the motor activity during 5 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In free-moving rabbits, intravenous DSIP significantly decreased motor activity over 5 hours.

    In plain wordsIn rabbits, DSIP given into a vein lowered movement for 5 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMotor activity
    Study

    rabbitn: not reported in source

    Free-moving rabbits
    Outcome group
    Sleep · Nervous system and cognition
    Studied dose
    30 nmoles/kg · intravenous · 5 hAs given in this study (rabbit).

    Source sentences

    Summary
    The synthetic delta sleep inducing peptide (DSIP) passes the blood-brain barrier, since i.v. injection in free moving rabbits (30 nmoles/kg) significantly increases the cortical delta activity and decreases the motor activity during 5 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.