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Study · Animal study (in vivo) · 1979

4 results

Action of posterior pituitary neuropeptides on the nigrostriatal dopaminergic system.

Schulz H, Kovács GL, Telegdy G

European journal of pharmacology1 Aug 1979Cited by 22 (Europe PMC)

PMID573691 (opens in a new tab)DOI10.1016/0014-2999(79)90364-9 (opens in a new tab)PepBankPUB-00573691
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In a unilateral nigral lesion model, PLG caused rotation toward the lesioned side.

    In plain wordsIn an animal lesion model, PLG caused rotation toward the lesioned side.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseIpsilateral rotation
    Study

    n: not reported in source

    unilateral 6-OHDA lesion of substantia nigra
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraventricularAs given in this study.

    Source sentences

    Summary
    Intraventricular injection of lysine8-vasopressin, oxytocin or PLG caused ipsilateral (towards the lesioned side) rotation, as did peripheral administration of amphetamine.
    1 context sentence
    Summary · context
    The effect of vasopressin, oxytocin and the C-terminal tripeptide of oxytocin, prolyl-leucyl-glycinamide (PLG), were tested on rotational behavior, following unilateral 6-OHDA-enduced lesion of the dopaminergic cell bodies in the substantia nigra.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In a unilateral nigral lesion model, oxytocin caused rotation toward the lesioned side.

    In plain wordsIn an animal lesion model, oxytocin caused rotation toward the lesioned side.

    Peptide
    Oxytocin
    Outcome
    IncreaseIpsilateral rotation
    Study

    n: not reported in source

    unilateral 6-OHDA lesion of substantia nigra
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraventricularAs given in this study.

    Source sentences

    Summary
    Intraventricular injection of lysine8-vasopressin, oxytocin or PLG caused ipsilateral (towards the lesioned side) rotation, as did peripheral administration of amphetamine.
    1 context sentence
    Summary · context
    The effect of vasopressin, oxytocin and the C-terminal tripeptide of oxytocin, prolyl-leucyl-glycinamide (PLG), were tested on rotational behavior, following unilateral 6-OHDA-enduced lesion of the dopaminergic cell bodies in the substantia nigra.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In a unilateral nigral lesion model, local PLG injection into the intact substantia nigra had no effect on rotation.

    In plain wordsIn an animal lesion model, local PLG injection into the intact substantia nigra did not change rotation.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeRotational behavior after local injection
    Study

    n: not reported in source

    unilateral 6-OHDA lesion of substantia nigra
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microinjection into intact substantia nigraAs given in this study.

    Source sentences

    Summary
    Direct local microinjection of the peptides into the substantia nigra on the intact side was without effect.
    1 context sentence
    Summary · context
    The effect of vasopressin, oxytocin and the C-terminal tripeptide of oxytocin, prolyl-leucyl-glycinamide (PLG), were tested on rotational behavior, following unilateral 6-OHDA-enduced lesion of the dopaminergic cell bodies in the substantia nigra.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In a unilateral nigral lesion model, local oxytocin injection into the intact substantia nigra had no effect on rotation.

    In plain wordsIn an animal lesion model, local oxytocin injection into the intact substantia nigra did not change rotation.

    Peptide
    Oxytocin
    Outcome
    No significant changeRotational behavior after local injection
    Study

    n: not reported in source

    unilateral 6-OHDA lesion of substantia nigra
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microinjection into intact substantia nigraAs given in this study.

    Source sentences

    Summary
    Direct local microinjection of the peptides into the substantia nigra on the intact side was without effect.
    1 context sentence
    Summary · context
    The effect of vasopressin, oxytocin and the C-terminal tripeptide of oxytocin, prolyl-leucyl-glycinamide (PLG), were tested on rotational behavior, following unilateral 6-OHDA-enduced lesion of the dopaminergic cell bodies in the substantia nigra.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

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