Assessment of the effects of vasoactive intestinal peptide (VIP) on blood flow through and salivation of the dog salivary gland in comparison with those of secretin, glucagon and acetylcholine.

Shimizu T, Taira N

British journal of pharmacology1 Apr 1979Cited by 48 (Europe PMC)

PMID435691PMCIDPMC1668682DOI10.1111/j.1476-5381.1979.tb07882.xPepBankPUB-00435691

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetised dogs, intra-arterial VIP produced a dose-dependent increase in blood flow through the submandibular gland artery (vasodilatation).
In plain wordsIn dogs, VIP given into the gland artery widened the blood vessels and raised blood flow, more so at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSubmandibular gland blood flow
Study
dogn: not reported in source
perfused submandibular gland in situ, anesthetised dogs
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
Vasoactive intestinal peptide (VIP), secretin and acetylcholine produced a dose-dependent increase in blood flow through the artery (vasodilatation) but glucagon was almost ineffective.
2 context sentences(design, population, supporting numbers)
Summary · context
The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs.
Summary · context
All drugs were administered intra-arterially.
Report a problemFND-0043569101
02AnimalAnimal study (in vivo)Activity measurement
In dogs, the dose-blood flow curves for VIP and secretin were parallel, and VIP was about 100 times as potent as secretin on a molar basis.
In plain wordsIn dogs, VIP was about 100 times more potent than secretin at raising blood flow in the gland.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicablePotency of VIP versus secretin on blood flow
Study
dogn: not reported in source
perfused submandibular gland in situ, anesthetised dogs
Comparator
Secretin
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Measurements
Relative molar potency versus secretin
100 fold
submandibular blood flow
Source sentences
Summary
Dose-blood flow response curves for VIP and secretin were parallel, and VIP was about 100 times as potent as secretin on a molar basis.
2 context sentences(design, population, supporting numbers)
Summary · context
The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs.
Summary · context
All drugs were administered intra-arterially.
Report a problemFND-0043569102
03AnimalAnimal study (in vivo)Efficacy outcome
In dogs, no tachyphylaxis developed to the vasodilator action of VIP.
In plain wordsIn dogs, the blood vessel widening caused by VIP did not fade with repeated use.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeTachyphylaxis to the vasodilator action of VIP
Study
dogn: not reported in source
perfused submandibular gland in situ, anesthetised dogs
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
No tachyphylaxis developed to the vasodilator action of VIP.
2 context sentences(design, population, supporting numbers)
Summary · context
The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs.
Summary · context
All drugs were administered intra-arterially.
Report a problemFND-0043569103
04AnimalAnimal study (in vivo)Mechanism
In dogs, the vasodilator response to VIP was scarcely modified by (-)-hyoscyamine, in doses that fully antagonized the response to acetylcholine.
In plain wordsIn dogs, a drug that fully blocked acetylcholine's effect hardly changed the blood vessel widening caused by VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of (-)-hyoscyamine on the VIP vasodilator response
Study
dogn: not reported in source
perfused submandibular gland in situ, anesthetised dogs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
The vasodilator responses to VIP and to electrical stimulation of the chordolingual nerve were scarcely modified by (-)-hyoscyamine in doses that fully antagonized the vasodilator response to acetylcholine.
2 context sentences(design, population, supporting numbers)
Summary · context
The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs.
Summary · context
All drugs were administered intra-arterially.
Report a problemFND-0043569104
05AnimalAnimal study (in vivo)Efficacy outcome
In dogs, VIP was ineffective in eliciting salivary secretion from the submandibular gland.
In plain wordsIn dogs, VIP did not cause the gland to make saliva.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSalivary secretion
Study
dogn: not reported in source
perfused submandibular gland in situ, anesthetised dogs
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
VIP, secretin and glucagon were ineffective in eliciting salivary secretion.
2 context sentences(design, population, supporting numbers)
Summary · context
The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs.
Summary · context
All drugs were administered intra-arterially.
Report a problemFND-0043569105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.