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Study · In vitro (cell-free) · rat · 1979

1 result

Enzyme kinetic studies and inhibition by oligopeptides of LH-RH degradation in rat hypothalamus and pituitary.

Kuhl H, Sandow J, Krauss B, Taubert HD

Neuroendocrinology1 Jan 1979Cited by 12 (Europe PMC)

PMID375117 (opens in a new tab)DOI10.1159/000122881 (opens in a new tab)PepBankPUB-00375117
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In rat hypothalamic and pituitary extracts, oxytocin weakly inhibited LH-RH degradation.

    In plain wordsIn lab tests, oxytocin weakly inhibited LH-RH degradation.

    Peptide
    Oxytocin
    Outcome
    DecreaseLH-RH degradation
    Study

    ratn: not reported in source

    hypothalamic and pituitary extracts
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most effective inhibitors of LH-RH degradation were found to be angiotensin-related peptides, neurotensin, bradykinin, and bacitracin. A relatively weak effect was obtained with oxytocin, enkephalin and puromycin.
    1 context sentence
    Summary · context
    The enzyme kinetic parameters of the degradation of luteinizing hormone-releasing hormone (LH-RH) and L-cystine-bis-(4-nitroanilide) (Cys-NA) by rat hypothalamic (HYP) and pituitary (PIT) extracts and the effect of various oligopeptides on the rate of LH-RH inactivation were investigated in vitro.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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