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Study · Not a test of the peptide alone · 1977

2 results

Neurophysin biosynthesis in normal rats and in rats with hereditary diabetes insipidus.

Brownstein MJ, Gainer H

Proceedings of the National Academy of Sciences of the United States of America1 Sept 1977Cited by 30 (Europe PMC)

PMID269451 (opens in a new tab)PMCIDPMC431838 (opens in a new tab)DOI10.1073/pnas.74.9.4046 (opens in a new tab)PepBankPUB-00269451
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, the observed pI 5.4 labeled peak, together with data presented elsewhere, indicated a separate oxytocin-neurophysin precursor.

    In plain wordsIn rats, an observed labeled peak, together with earlier data, indicated a separate oxytocin-neurophysin precursor.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-neurophysin precursor synthesis
    Study

    ratn: not reported in source

    supraoptic nucleus and posterior pituitary
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Measurements

    precursor pI
    5.4 pI
    oxytocin-neurophysin precursor

    Source sentences

    Summary
    Twenty minutes after the injection of [35S]cysteine, two major labeled peaks (pI = 5.4 and 6.1) were found in the SON of normal rats; Brattleboro rats had only one major labeled peak (pI = 5.4).
    1 context sentence
    Summary · context
    These pulse-chase data, with data we have presented elsewhere, indicate that the vasopressin- and oxytocin-neurophysins are synthesized as parts of separate precursors (pI = 6.1 and 5.4, respectively).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, observed labeled proteins with pI 5.1 and 4.6, together with data presented elsewhere, indicated processing to oxytocin-neurophysin.

    In plain wordsIn rats, observed labeled proteins, together with earlier data, indicated processing to oxytocin-neurophysin.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-neurophysin processing intermediate
    Study

    ratn: not reported in source

    supraoptic nucleus and posterior pituitary
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Measurements

    intermediate pI
    5.1 pI
    oxytocin-neurophysin pathway
    oxytocin-neurophysin pI
    4.6 pI
    oxytocin-neurophysin

    Source sentences

    Summary
    Animals with diabetes insipidus had only two major labeled proteins (pI = 5.1 AND 5.4).
    3 context sentences
    Summary · context
    After 24 hr the posterior pituitary of normal animals contained two [35S]cysteine-labeled proteins with pI = 4.6 AND 4.8. The pituitaries of Brattleboro rats had only the pI = 4.6 labeled protein.
    Summary · context
    These pulse-chase data, with data we have presented elsewhere, indicate that the vasopressin- and oxytocin-neurophysins are synthesized as parts of separate precursors (pI = 6.1 and 5.4, respectively).
    Summary · context
    These precursors are converted into at least two intermediates (pI = 5.6 and 5.1) which, in turn, yield the vasopressin-neurophysin (pI = 4.8) and the oxytocin-neurophysin (pI = 4.6).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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