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Study · Ex vivo tissue · toad · 1978

3 results

Synthesis and characterization of 2-nitro-5-aziodobenzoylglycyloxytocin, an oxytocin photoaffinity label.

Stadel JM, Goodman DB, Galardy RE, Rasmussen H

Biochemistry1 Apr 1978Cited by 8 (Europe PMC)

PMID206276 (opens in a new tab)DOI10.1021/bi00601a007 (opens in a new tab)PepBankPUB-00206276
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In toad urinary bladder tissue, excess oxytocin (10(-6)M) during photolysis relieved photoaffinity-label inhibition of oxytocin-stimulated urea permeability.

    In plain wordsIn lab tests, excess oxytocin during photolysis relieved the label-induced inhibition of oxytocin-stimulated urea permeability.

    Peptide
    Oxytocin
    Outcome
    DecreasePhotoaffinity-label inhibition of urea permeability
    Study

    toadn: not reported in source

    urinary bladder
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    10(-6)MAs given in this study (toad).

    Source sentences

    Summary
    The inhibition is dependent on the photogeneration of the aryl nitrene intermediate and is relieved by protecting the hormone receptor with excess oxytocin (10(-6)M) during the photolysis.
    1 context sentence
    Summary · context
    Repetitive photolysis in the presence of NAB-Gly-oxytocin (8 X 10(-6)M) results in a progressive permanent inhibition of oxytocin stimulated urea permeability but does not alter hormone induced 3H2O movement.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In toad urinary bladder tissue, photolysis in the presence of NAB-Gly-oxytocin progressively and permanently inhibited oxytocin-stimulated urea permeability.

    In plain wordsIn lab tests, the photoaffinity label permanently reduced the urea-permeability response stimulated by oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-stimulated urea permeability after photolysis
    Study

    toadn: not reported in source

    urinary bladder
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    Repetitive photolysis in the presence of NAB-Gly-oxytocin (8 X 10(-6)M) results in a progressive permanent inhibition of oxytocin stimulated urea permeability but does not alter hormone induced 3H2O movement.
    1 context sentence
    Summary · context
    The oxytocin analogue, 2-nitro-5-azidobenzoylglycyloxytocin (NAB-Gly-oxytocin), has been synthesized and purified.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In toad urinary bladder tissue, photolysis in the presence of NAB-Gly-oxytocin did not alter oxytocin-induced 3H2O movement.

    In plain wordsIn lab tests, the photoaffinity label did not alter oxytocin-induced water movement.

    Peptide
    Oxytocin
    Outcome
    No significant changeHormone-induced water movement after photolysis
    Study

    toadn: not reported in source

    urinary bladder
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    Repetitive photolysis in the presence of NAB-Gly-oxytocin (8 X 10(-6)M) results in a progressive permanent inhibition of oxytocin stimulated urea permeability but does not alter hormone induced 3H2O movement.
    1 context sentence
    Summary · context
    The oxytocin analogue, 2-nitro-5-azidobenzoylglycyloxytocin (NAB-Gly-oxytocin), has been synthesized and purified.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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