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Study · In vitro (cells) · mouse · 1977

3 results

Effect of a human serum thymic factor on hydrocortisone-treated thymocytes.

Astaldi GC, Astaldi A, Groenewoud M, Wijermans P, Schellekens PT, Eijsvoogel VP

European journal of immunology1 Dec 1977Cited by 18 (Europe PMC)

PMID204496 (opens in a new tab)DOI10.1002/eji.1830071203 (opens in a new tab)PepBankPUB-00204496
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In normal mouse thymocytes, human serum thymic factor stimulated cAMP synthesis.

    In plain wordsIn cells from mice, human serum thymic factor increased cAMP production.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasecAMP synthesis in normal thymocytes
    Study

    mousen: not reported in source

    Thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A human serum thymic factors (SF) stimulated cyclic adenosine-3' ,5'-monophosphate (cAMP) synthesis in normal mouse thymocytes.
  2. 02LabIn vitro (cells)Mechanism

    In mouse thymocytes depleted of hydrocortisone-sensitive cells, serum thymic factor no longer stimulated cAMP synthesis.

    In plain wordsIn cells from mice, serum thymic factor no longer increased cAMP after removal of hydrocortisone-sensitive cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changecAMP stimulation after depletion of HC-sensitive cells
    Study

    mousen: not reported in source

    Mouse thymocytes depleted of hydrocortisone-sensitive cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Such stimulation was no longer observed when thymocytes were depleted of hydrocortisone (HC)-sensitive cells.
    1 context sentence
    Summary · context
    A human serum thymic factors (SF) stimulated cyclic adenosine-3' ,5'-monophosphate (cAMP) synthesis in normal mouse thymocytes.
  3. 03LabIn vitro (cells)Mechanism

    In mouse thymocytes, incubation with serum thymic factor enlarged the hydrocortisone-resistant population.

    In plain wordsIn cells from mice, serum thymic factor increased the population of hydrocortisone-resistant thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseHC-resistant thymocyte population
    Study

    mousen: not reported in source

    Thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, incubation of thymocytes with SF enlarged the population of HC-resistant thymocytes.
    1 context sentence
    Summary · context
    A human serum thymic factors (SF) stimulated cyclic adenosine-3' ,5'-monophosphate (cAMP) synthesis in normal mouse thymocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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