Sodium pump stimulation by oxytocin and cyclic AMP in the isolated epithelium of the frog skin.

Aceves J

Pflugers Archiv : European journal of physiology1 Nov 1977Cited by 8 (Europe PMC)

PMID202919DOI10.1007/bf00586260PepBankPUB-00202919

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In isolated frog skin epithelium, oxytocin significantly stimulated sodium extrusion at 3.5 mM potassium.
In plain wordsIn lab tests of isolated frog skin epithelium, oxytocin increased sodium extrusion at normal potassium.
Peptide
Oxytocin
Outcome
IncreaseSodium extrusion at normal extracellular potassium
Study
frogn: not reported in source
isolated skin epithelium
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of the Na pump was judged by Na extrusion in epithelial cells loaded with Na by a previous incubation in K-free solutions in the cold.
Report a problemFND-0020291901
02LabEx vivo tissueActivity measurement
In isolated frog skin epithelium, oxytocin significantly stimulated sodium extrusion at 0.25 mM potassium.
In plain wordsIn lab tests of isolated frog skin epithelium, oxytocin increased sodium extrusion at low potassium.
Peptide
Oxytocin
Outcome
IncreaseSodium extrusion at low extracellular potassium
Study
frogn: not reported in source
isolated skin epithelium
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium.
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of the Na pump was judged by Na extrusion in epithelial cells loaded with Na by a previous incubation in K-free solutions in the cold.
Report a problemFND-0020291902
03LabEx vivo tissueActivity measurement
In isolated frog skin epithelium, at maximal concentrations oxytocin stimulated sodium extrusion to about the same degree as cyclic AMP.
In plain wordsIn lab tests of isolated frog skin epithelium, maximal oxytocin stimulation was about the same as cyclic AMP.
Peptide
Oxytocin
Outcome
Not applicableMaximum sodium-extrusion stimulation versus cyclic AMP
Study
frogn: not reported in source
isolated skin epithelium
Comparator
cyclic AMP
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium. It was stimulated as well by cyclic AMP. Maximal concentrations of either agent caused about the same degree of stimulation.
Report a problemFND-0020291903

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

04LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In isolated frog skin epithelium, ouabain prevented oxytocin's stimulation of sodium extrusion.
In plain wordsIn lab tests of isolated frog skin epithelium, ouabain prevented oxytocin's stimulation of sodium extrusion.
Peptide
Oxytocin
Outcome
DecreaseOxytocin action after ouabain addition
Study
frogn: not reported in source
isolated skin epithelium
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium. It was stimulated as well by cyclic AMP. Maximal concentrations of either agent caused about the same degree of stimulation. Addition of ouabain or removal of K prevented the action of both age…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0020291904
05LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In isolated frog skin epithelium, potassium removal prevented oxytocin's stimulation of sodium extrusion.
In plain wordsIn lab tests of isolated frog skin epithelium, potassium removal prevented oxytocin's stimulation of sodium extrusion.
Peptide
Oxytocin
Outcome
DecreaseOxytocin action after potassium removal
Study
frogn: not reported in source
isolated skin epithelium
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium. It was stimulated as well by cyclic AMP. Maximal concentrations of either agent caused about the same degree of stimulation. Addition of ouabain or removal of K prevented the action of both age…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0020291905
06LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In isolated frog skin epithelium, amiloride had no effect on oxytocin's stimulation of sodium extrusion.
In plain wordsIn lab tests of isolated frog skin epithelium, amiloride did not affect oxytocin's stimulation of sodium extrusion.
Peptide
Oxytocin
Outcome
No significant changeOxytocin action after amiloride
Study
frogn: not reported in source
isolated skin epithelium
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Oxytocin significantly stimulated Na extrusion either at normal (3.5 mM) or low (0.25 mM) K in the medium. It was stimulated as well by cyclic AMP. Maximal concentrations of either agent caused about the same degree of stimulation. Addition of ouabain or removal of K prevented the action of both age…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0020291906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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