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Study · Randomized controlled trial · n = 94 · 1979

3 results

A double-blind trial of synthetic salmon calcitonin in the treatment of acute pancreatitis.

Goebell H, Ammann R, Herfarth C, Horn J, Hotz J, Knoblauch M, Schmid M, Jaeger M, Akovbiantz A, Linder E, Abt K, Nüesch E, Barth E

Scandinavian journal of gastroenterology1 Jan 1979Cited by 36 (Europe PMC)

PMID94176 (opens in a new tab)DOI10.3109/00365527909181420 (opens in a new tab)PepBankPUB-00094176
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In acute pancreatitis, salmon calcitonin did not influence mortality versus placebo, with overall mortality of 5.3%.

    In plain wordsIn acute pancreatitis, salmon calcitonin did not change mortality compared with placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeMortality
    Study

    n = 94

    Comparator
    Placebo
    Outcome group
    Mortality · Whole body
    Studied dose
    3 x 20 micrograms = 300 MRCU daily · intravenous · 6 daysAs given in this study (human).

    Measurements

    Overall mortality
    5.3%
    both groups combined

    Source sentences

    Summary
    Mortality rate was not influenced, overall mortality being 5.3%.
    2 context sentences
    Summary · context
    A multicenter randomized double-blind trial on the use of synthetic salmon calcitonin (SCT) was carried out in 94 patients with acute pancreatitis.
    Summary · context
    In addition to strict standard treatment--without aprotinin, atropine, or antacids--50 patients received daily 3 x 20 micrograms = 300 MRCU SCT intravenously and 44 patients received placebo for 6 days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In acute pancreatitis, salmon calcitonin increased the number of patients without pain and with normalized amylase versus placebo.

    In plain wordsIn acute pancreatitis, more patients had no pain and normal amylase with salmon calcitonin than with placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePain-free patients with normalized amylase
    Study

    n = 94

    Comparator
    Placebo
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    3 x 20 micrograms = 300 MRCU daily · intravenous · 6 daysAs given in this study (human).

    Source sentences

    Summary
    The number of patients without pain and with normalized serum amylase on a given day was significantly higher in the group treated with SCT.
    2 context sentences
    Summary · context
    A multicenter randomized double-blind trial on the use of synthetic salmon calcitonin (SCT) was carried out in 94 patients with acute pancreatitis.
    Summary · context
    In addition to strict standard treatment--without aprotinin, atropine, or antacids--50 patients received daily 3 x 20 micrograms = 300 MRCU SCT intravenously and 44 patients received placebo for 6 days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In acute pancreatitis, analgesic doses, leukocyte count, and normalization of seven criteria showed favorable nonsignificant trends with salmon calcitonin versus placebo.

    In plain wordsIn acute pancreatitis, analgesic doses, leukocyte count, and normalization of seven criteria showed favorable nonsignificant trends with salmon calcitonin versus placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeOther clinical and laboratory parameters
    Study

    n = 94

    Comparator
    Placebo
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    3 x 20 micrograms = 300 MRCU daily · intravenous · 6 daysAs given in this study (human).

    Source sentences

    Summary
    Other parameters such as doses of analgesics, leukocyte count, and normalization of seven defined clinical and laboratory criteria within 6 days showed a positive trend without reaching significance.
    2 context sentences
    Summary · context
    A multicenter randomized double-blind trial on the use of synthetic salmon calcitonin (SCT) was carried out in 94 patients with acute pancreatitis.
    Summary · context
    In addition to strict standard treatment--without aprotinin, atropine, or antacids--50 patients received daily 3 x 20 micrograms = 300 MRCU SCT intravenously and 44 patients received placebo for 6 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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