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Study · Animal study (in vivo) · rat · 1979

4 results

Effect of desglycinamide(9)-lysine(8)-vasopressin and prolyl-leucyl-glycinamide on oral ethanol intake in the rat.

Mucha RF, Kalant H

Pharmacology, biochemistry, and behavior1 Feb 1979Cited by 23 (Europe PMC)

PMID36634 (opens in a new tab)DOI10.1016/0091-3057(79)90092-3 (opens in a new tab)PepBankPUB-00036634
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, daily PLG augmented the increase in accepted ethanol concentrations.

    In plain wordsIn rats, daily PLG increased the rise in accepted ethanol concentrations.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseEthanol concentration accepted
    Study

    ratn: not reported in source

    ethanol drinking
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    10 microgram daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    These increases were augmented when daily subcutaneous injections of 1 microgram of desglycinamide9-lysine8-vasopressin (DGLVP) or 10 microgram of prolyl-leucyl-glycinamide (PLG) were given concomitantly.
    1 context sentence
    Summary · context
    Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, daily PLG augmented the increase in ethanol consumption.

    In plain wordsIn rats, daily PLG increased the rise in ethanol consumption.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseEthanol consumption
    Study

    ratn: not reported in source

    ethanol drinking
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    10 microgram daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    These increases were augmented when daily subcutaneous injections of 1 microgram of desglycinamide9-lysine8-vasopressin (DGLVP) or 10 microgram of prolyl-leucyl-glycinamide (PLG) were given concomitantly.
    1 context sentence
    Summary · context
    Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG produced no significant change in ethanol consumption.

    In plain wordsIn rats, PLG did not significantly change ethanol consumption.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeEthanol consumption
    Study

    ratn: not reported in source

    ethanol drinking
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    1 microgram · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Nonsignificant changes in ethanol consumption were seen with injections of 1 microgram PLG, or 0.42 or 42 microgram of lysine8-vasopressin (LVP).
    1 context sentence
    Summary · context
    Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol.

Studies that did not test the peptide alone1

In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

  1. 04AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Efficacy outcome

    In rats offered ethanol and water, pooled peptide tests showed only marginal evidence of changes in ethanol intake.

    In plain wordsIn rats offered ethanol and water, pooled peptide tests showed only marginal evidence of changes in ethanol intake.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Direction not reportedEthanol intake during free choice
    Study

    ratn: not reported in source

    ethanol drinking
    Outcome group
    Appetite and food intake · Nervous system and cognition

    Source sentences

    Summary
    On these tests there was only marginal evidence of peptide-produced changes in ethanol intake.
    2 context sentences
    Summary · context
    In both Experiments 1 and 2, the rats were switched from forced ethanol intake to a choice between ethanol and tap water.
    Summary · context
    Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol.

    In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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