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Study · Ex vivo tissue · rat · 1978

5 results

The degradation of a nonapeptide, sleep inducing peptide, in rat brain: comparison with enkephalin breakdown.

Huang JT, Lajtha A

Research communications in chemical pathology and pharmacology1 Feb 1978Cited by 16 (Europe PMC)

PMID25463 (opens in a new tab)PepBankPUB-00025463
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat brain homogenate, 30% of N-terminal tryptophan was released from DSIP after 7.5 minutes, against 75% of N-terminal tyrosine from Met-enkephalin.

    In plain wordsIn rat brain tissue extract, less of DSIP's first amino acid was released than of Met-enkephalin's after 7.5 minutes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableN-terminal tryptophan released from DSIP
    Study

    ratn: not reported in source

    Brain homogenate
    Comparator
    Met-enkephalin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    N-terminal Trp released
    30%
    DSIP, 7.5 min incubation, 2.5% homogenate

    Source sentences

    Summary
    After 7.5 minutes of incubation of 2.5% (w/v) homogenate, 30% of N-terminal tryptophan was released from DSIP, while 75% of N-terminal tyrosine was released from Metenkephalin.
    1 context sentence
    Summary · context
    The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates.
  2. 02LabEx vivo tissueMechanism

    In rat brain homogenate, the optimal pH for degradation of DSIP, as for Met-enkephalin, was 7.35.

    In plain wordsIn rat brain tissue extract, DSIP broke down fastest at pH 7.35.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableOptimal pH of DSIP degradation
    Study

    ratn: not reported in source

    Brain homogenate
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Optimal pH of degradation
    7.35 pH
    DSIP and Met-enkephalin

    Source sentences

    Summary
    The optimal pH of degradation of both peptides was pH 7.35.
    1 context sentence
    Summary · context
    The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates.
  3. 03LabEx vivo tissueMechanism

    In rat brain homogenate, breakdown of DSIP rose rapidly during the first 10 days of postnatal growth.

    In plain wordsIn rat brain tissue extract, DSIP broke down faster as young rats grew over their first 10 days.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP breakdown during postnatal growth
    Study

    ratn: not reported in source

    Brain homogenate
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A rapid increase of breakdown of the peptides was observed during the 10 days of postnatal growth, with breakdown expressed per unit weight of brain.
    1 context sentence
    Summary · context
    The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates.
  4. 04LabEx vivo tissueMechanism

    In rat brain homogenate, morphine did not affect the degradation of DSIP.

    In plain wordsIn rat brain tissue extract, morphine did not change how fast DSIP broke down.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP degradation with morphine
    Study

    ratn: not reported in source

    Brain homogenate
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither morphine nor deprivation of rapid eye movement (REM) sleep affected the degradation of peptides
    1 context sentence
    Summary · context
    The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates.
  5. 05LabEx vivo tissueMechanism

    In rat brain homogenate, REM sleep deprivation did not affect the degradation of DSIP.

    In plain wordsIn rat brain tissue extract, REM sleep deprivation did not change how fast DSIP broke down.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP degradation with REM sleep deprivation
    Study

    ratn: not reported in source

    Brain homogenate
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither morphine nor deprivation of rapid eye movement (REM) sleep affected the degradation of peptides.
    1 context sentence
    Summary · context
    The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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