In rats in the DOPA-potentiation test, increased behavioral responses to MIF-I correlated with increased striatal dopamine, especially in younger animals.
In plain wordsIn rats given the DOPA regimen, greater behavioral responses to MIF-I correlated with higher striatal dopamine, especially in younger animals.
- Peptide
- MIF-1 (Pro-Leu-Gly-NH2)
- Outcome
- IncreaseBehavioral response correlation with striatal dopamine
- Study
ratn: not reported in source
DOPA-potentiation test- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
Source sentences
In general, especially among the younger animals, a significant correlation (p=0.05 to p=0.01) was found between the increased behavioral responses to MIF-I and the rise in DA.
3 context sentences(design, population, supporting numbers)
The DOPA potentiation test was performed as follows: 2-4 hr before behavior measurement, 40 mg/kg of the monoamine oxidase inhibitor pargyline HCl was given orally.
Two hr later this was followed by the intraperitoneal (IP) injection of MIF-1 at doses of 0.1, 0.3 or 1.0 mg/kg.
Behavioral measurement was begun after the IP injection of 200 mg/kg of dl-DOPA 1-2 hr after the MIF-1.
In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).