MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
Hudson Biotech120 participants2 Feb 2026 to est. 17 May 2028
Prediabetes · Insulin Resistance · Overweight/Obesity
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
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| Peptide | Synthetic analog Epitalon | Natural peptide MOTS-c | |
|---|---|---|---|
| Identity | |||
| Kind | Synthetic analog | Natural peptide | |
| Area | Longevity and mitochondria | Longevity and mitochondria | |
| Evidence | |||
| Amount of evidence | 290 | 697 (plus 348 on natural levels, listed separately) | |
| Evidence level | Has results from studies in people | Results from animal studies onlyRegistered trials, no results from human studies | |
| Safety | |||
| Safety results | 4 (0 in people) | 12 (0 in people) | |
| Status | |||
| Approval | |||
| Sport (WADA) | |||
| Registered trials | None registered | 1 · 1 active3 more mention it but do not test it | |
Shared outcomes
From the regulatory data of each peptide.
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
| Outcome group | Epitalon | MOTS-c |
|---|---|---|
| Receptor activity and mechanismPharmacology | 268162 | 16491 |
PepBank is a research reference. Talk to a doctor before you use any peptide.
Its most advanced trial is in phase 2. The FDA, the EMA and the other sources we use show no approval (as of 30 Oct 2026).
| Aging markersWhole body | 7944233 | 835 |
|---|
| Inflammation markersNervous system and cognition | 22 | 937518 |
|---|
| Mitochondrial functionAging and longevity | 22 | 873651 |
|---|
| Tumor growthCancer | 5151 | 615 |
|---|
| NeuroprotectionNervous system and cognition | 17710 | 312110 |
|---|
| Glycemic controlMetabolic and weight | 88 | 321913 |
|---|
| Immune responseImmune and inflammation | 21156 | 11 |
|---|
| Oxidative stressAging and longevity | 44 | 15114 |
|---|
| Sex hormones and fertilityReproductive and sexual health | 1046 | 99 |
|---|
| Body weightMetabolic and weight | 44 | 1010 |
|---|
| Exercise and physical functionWhole body | 55 | 99 |
|---|
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
No registered trial that tests Epitalon found in ClinicalTrials.gov.
1 trial · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)
Hudson Biotech120 participants2 Feb 2026 to est. 17 May 2028
Prediabetes · Insulin Resistance · Overweight/Obesity
3 more mention it but do not test it. They only measure it or name it in their text.