In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Comparing 2 peptides · Data version 308560
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| Peptide | Natural peptide Amylin, human (islet amyloid polypeptide) | Synthetic analog Cagrilintide | |
|---|---|---|---|
| Identity | |||
| Kind | Natural peptide | Synthetic analog | |
| Area | Weight and metabolic | Weight and metabolic | |
| Evidence | |||
| Amount of evidence | No results yet | 130 | |
| Evidence level | No study results | Has results from studies in people | |
| Safety | |||
| Safety results | No safety results | 28 (28 in people) | |
| Status | |||
| Approval | |||
| Sport (WADA) | |||
| Registered trials | None registered | 53 · 18 active1 more mentions it but does not test it | |
From the regulatory data of each peptide.
Its most advanced trial is in phase 2. The FDA, the EMA and the other sources we use show no approval (as of 9 Oct 2026).
Outcome groups with study results for at least two of these peptides. Counts include only results from studies that gave the peptide. Bar length is the number of results, on one scale. The bars show how much was studied, not how large an effect was. A peptide with more studies can look stronger here without being stronger. For results, see the randomized results above.
No outcome group has study results for two or more of these peptides.
PepBank is a research reference. Talk to a doctor before you use any peptide.
Its most advanced trial is in phase 3. The FDA, the EMA and the other sources we use show no approval (as of 9 Oct 2026).
Each analog against its native parent, residue by residue. Substitutions, non-standard residues and modifications are marked. Calculated from the two sequences.
Cagrilintide differs from Amylin, human (islet amyloid polypeptide) at 6 positions and carries 2 added groups.
What is different
For each outcome that two or more peptides have results for: the best result of a single randomized trial, on the same measure (the same kind of number, the same unit). When a trial has several dose arms, the cell shows the highest dose arm. The trials differ in people, length and dose, so a gap between two cells is not proof that one peptide works better.
No outcome has a randomized-trial result on the same measure for two or more of these peptides yet.
Registered trials, ranked by phase (late phases first), then posted results and enrollment. Status is the registry status. Study results come from published studies. Results posted at ClinicalTrials.gov are shown on each trial page.
No registered trial that tests Amylin, human (islet amyloid polypeptide) found in ClinicalTrials.gov.
Top 3 of 53 trials, ranked by phase, then posted results and enrollment: 2 ongoing · 1 completed · source ClinicalTrials.gov (opens in a new tab)
Novo Nordisk A/S7,101 participants1 Mar 2023 to est. 14 Oct 2027
Cardiovascular Disease
Novo Nordisk A/S3,400 participants1 Nov 2022 to est. 19 Oct 2026
Obesity
Novo Nordisk A/S2,734 participants27 Sept 2023 to 6 Jan 2026
Type 2 Diabetes Mellitus
1 more mentions it but does not test it. They only measure it or name it in their text.